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Conventional asthma therapies, such as corticosteroids, long-acting \u03b2-agonists, and anti-inflammatory agents, often evoke diverse adverse reactions and fail to reduce symptoms and hospitalization rates over the long term effectively. These limitations have prompted researchers to explore innovative therapeutic strategies, including stem cell-related interventions, offering hope to those afflicted with this incurable disease. In this review, we describe the characteristics of stem cells and critically assess the potential and challenges of stem cell-based therapies to improve disease management and treatment outcomes for asthma and other diseases.<\/jats:p>","DOI":"10.4252\/wjsc.v17.i2.103599","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T01:57:16Z","timestamp":1740362236000},"source":"Crossref","is-referenced-by-count":3,"title":["Asthma and stem cell therapy"],"prefix":"10.4252","volume":"17","author":[{"given":"Qiong-Hua","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Yang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Chun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210531"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/s0031-3955(03)00044-0"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(01)01033-6"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.90.4.480"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2019_460"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.047"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-017-0160-0"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-2-21"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33311-1"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/197452a0"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/2001-1326-3-15"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1716145"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2018.01.013"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-015-1918-6"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.317"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1241"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1177\/10815589221140590"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802307R"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0499-0"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.898312"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1570"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-196803000-00009"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5411.143"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3057624"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.8.5.569"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.07.011"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.01.022"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.108021"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010099"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00288.2011"},{"key":"B32","unstructured":"Li JW, Wu X. 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