{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:51:49Z","timestamp":1790653909438,"version":"4.1.0"},"reference-count":66,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Stem Cells"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Mesenchymal stem cells (MSCs) and their secretome have significant potential in promoting hair follicle development. However, the effects of MSC therapy have been reported to vary due to their heterogeneous characteristics. Different sources of MSCs or culture systems may cause heterogeneity of exosomes.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To define the potential of human adipose-derived MSC exosomes (hADSC-Exos) and human umbilical cord-derived MSC exosomes (hUCMSC-Exos) for improving dermal papillary cell proliferation in androgenetic alopecia.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>We conducted liquid chromatography-mass spectrometry proteomic analysis of hADSC-Exos and hUCMSC-Exos. Liquid chromatography-mass spectrometry suggested that hADSC-Exos were related to metabolism and immunity. Additionally, the hADSC-Exo proteins regulated the cell cycle and other 9 functional groups.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>We verified that hADSC-Exos inhibited glycogen synthase kinase-3\u03b2 expression by activating the Wnt\/\u03b2-catenin signaling pathway via  cell division cycle protein 42, and enhanced dermal papillary cell proliferation and migration. Excess dihydrotestosterone caused androgenetic alopecia by shortening the hair follicle growth phase, but hADSC-Exos reversed these effects.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>This study indicated that hair development is influenced by hADSC-Exo-mediated cell-to-cell communication via  the Wnt\/\u03b2-catenin pathway.<\/jats:p>","DOI":"10.4252\/wjsc.v17.i3.102088","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T05:40:27Z","timestamp":1742362827000},"source":"Crossref","is-referenced-by-count":22,"title":["Mesenchymal stem cell exosomes enhance the development of hair follicle to ameliorate androgenetic 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