{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:21:22Z","timestamp":1794007282997,"version":"4.8.0"},"reference-count":36,"publisher":"Baishideng Publishing Group Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Stem Cells"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Traumatic spinal cord injury (SCI) is a life-altering condition that results in long-term complications, including progressive neurodegeneration and cord atrophy. It presents a significant unmet medical need with extensive social and economic burdens.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To evaluate the safety and preliminary efficacy of allogeneic mesenchymal stem cells derived from Wharton\u2019s jelly (WJ-MSCs) in patients with chronic complete SCI. The primary objective was to assess whether WJ-MSCs could facilitate neurological recovery and improve the quality of life in this patient population.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>This open-label, multicenter phase I study investigated the effects of administering WJ-MSCs via  three delivery routes: Intrathecal (for localized spinal targeting); intramuscular (for targeting end organ); and intravenous (for systemic immunomodulation). While all three routes were used concurrently to enhance therapeutic synergy, neurological, sensory, and functional scales were used to assess overall efficacy. Participants with chronic SCI (duration of at least 6 months) who had significant impairment and disability were eligible for inclusion. WJ-MSCs were administered twice monthly for 2 months, with each route receiving a dose of 1 \u00d7 106 cells\/kg. Patients were closely monitored for 1 year following treatment.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>At baseline, participants displayed considerable functional deficits, as indicated by the following scores: Functional independence measure of 77.5 \u00b1 2.26; Modified Ashworth Scale of 15.83 \u00b1 4.83; American Spinal Injury Association (ASIA) Motor score of 1.67 \u00b1 2.66; ASIA Light Touch and Pin-Prick scores of 62 \u00b1 18.42 each; Wexner Incontinence Score of 20; and Qualiveen Short Form, a validated questionnaire specifically designed to assess the impact of urinary dysfunction on quality of life in individuals with SCI, score of 32. Following WJ-MSC therapy, significant improvements were observed in all neurological functions over the 1-year follow-up. Notably, the ASIA Motor score improved significantly (\u03c7 2 = 23.938, P  &lt; 0.001), and Qualiveen Short Form scores demonstrated a substantial enhancement in quality of life (z  = -2.214, P  &lt; 0.05).<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>This phase I study, conducted without a control group, suggests that the administration of WJ-MSCs through multiple routes is both safe and potentially effective in patients with chronic complete SCI. However, the observed neurological improvements cannot be solely attributed to WJ-MSC therapy, as concurrent pharmacological and rehabilitative interventions were not controlled. These findings indicated that WJ-MSC therapy may offer a promising approach for enhancing neurological function and quality of life in this challenging patient population. Further research with larger cohorts and extended follow-up is necessary to validate these preliminary results.<\/jats:p>","DOI":"10.4252\/wjsc.v17.i5.101675","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T22:35:28Z","timestamp":1747953328000},"source":"Crossref","is-referenced-by-count":13,"title":["Multiroute administration of Wharton\u2019s jelly mesenchymal stem cells in chronic complete spinal cord injury: A phase I safety and feasibility study"],"prefix":"10.4252","volume":"17","author":[{"given":"Necati","family":"Kaplan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Kabatas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdin\u00e7","family":"Civelek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ey\u00fcp Can","family":"Savrunlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolga","family":"Akkoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Boyal\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erek","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Genc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdal","family":"Kara\u00f6z","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2017.1329076"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2147\/JN.S143236"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2010.146"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2011.178"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00282"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4055\/cios.2017.9.1.1"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200112151-00002"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(06)61009-1"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1089\/0897715041269641"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001046.pub2"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.5137\/1019-5149.JTN.15724-15.0"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.4149\/BLL_2018_028"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v13.i5.470"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4274\/jtss.galenos.2021.363"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1177\/0963689717746999"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-019-02502-7"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/s0361-9230(01)00774-2"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4890-04.2005"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-005-0538-y"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3727\/000000004773301780"},{"key":"B21","unstructured":"Malgieri A, Kantzari E, Patrizi MP, Gambardella S. 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