{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T06:11:03Z","timestamp":1774332663444,"version":"3.50.1"},"reference-count":35,"publisher":"Baishideng Publishing Group Inc.","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Endosc"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Ulcerative colitis (UC) with concomitant primary sclerosing cholangitis (PSC) represents a distinct disease entity (PSC-UC). Mayo endoscopic subscore (MES) is a standard tool for assessing disease activity in UC but its relevance in PSC-UC remains unclear.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To assess the accuracy of MES in UC and PSC-UC patients, we performed histological scoring using Nancy histological index (NHI).<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>MES was assessed in 30 PSC-UC and 29 UC adult patients during endoscopy. NHI and inflammation were evaluated in biopsies from the cecum, rectum, and terminal ileum. In addition, perinuclear anti-neutrophil cytoplasmic antibodies, fecal calprotectin, body mass index, and other relevant clinical characteristics were collected.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>The median MES and NHI were similar for UC patients (MES grade 2 and NHI grade 2 in the rectum) but were different for PSC-UC patients (MES grade 0 and NHI grade 2 in the cecum). There was a correlation between MES and NHI for UC patients (Spearman's r  = 0.40, P  = 0.029) but not for PSC-UC patients. Histopathological examination revealed persistent microscopic inflammation in 88% of PSC-UC patients with MES grade 0 (46% of all PSC-UC patients). Moreover, MES overestimated the severity of active inflammation in an additional 11% of PSC-UC patients.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>MES insufficiently identifies microscopic inflammation in PSC-UC. This indicates that histological evaluation should become a routine procedure of the diagnostic and grading system in both PSC-UC and PSC.<\/jats:p>","DOI":"10.4253\/wjge.v16.i11.607","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T20:09:32Z","timestamp":1730232572000},"page":"607-616","source":"Crossref","is-referenced-by-count":3,"title":["Limited validity of Mayo endoscopic subscore in ulcerative colitis with concomitant primary sclerosing cholangitis"],"prefix":"10.4253","volume":"16","author":[{"given":"Pavel","family":"Wohl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alzbeta","family":"Krausova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Wohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ondrej","family":"Fabian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Bajer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Brezina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Drastich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojmir","family":"Hlavaty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Novotna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Kahle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius","family":"Spicak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Gregor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.10.870"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.046615"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.02.038"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21699"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7969628"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22938"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i6.1956"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.11.067"},{"key":"B9","doi-asserted-by":"crossref","unstructured":"Loftus EV Jr, Sandborn WJ, Lindor KD, Larusso NF. 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