{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T03:03:07Z","timestamp":1788058987403,"version":"build-2784847793"},"reference-count":33,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Endosc"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Endoscopic retrograde cholangiopancreatography (ERCP) is an essential therapeutic tool for biliary and pancreatic diseases. Frail and elderly patients, especially those aged \u2265 90 years are generally considered a higher-risk population for ERCP-related complications.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To investigate outcomes of ERCP in the Non-agenarian population (\u2265 90 years) concerning Frailty.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>This is a cohort study using the 2018-2020 National Readmission Database. Patients aged \u2265 90 were identified who underwent ERCP, using the international classification of diseases-10 code with clinical modification. Johns Hopkins\u2019s adjusted clinical groups frailty indicator was used to classify patients as frail and non-frail. The primary outcome was mortality, and the secondary outcomes were morbidity and the 30 d readmission rate related to ERCP. We used univariate and multivariate regression models for analysis.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>A total of 9448 patients were admitted for any indications of ERCP. Frail and non-frail patients were 3445 (36.46%) and 6003 (63.53%) respectively. Indications for ERCP were Choledocholithiasis (74.84%), Biliary pancreatitis (9.19%), Pancreatico-biliary cancer (7.6%), Biliary stricture (4.84%), and Cholangitis (1.51%). Mortality rates were higher in frail group [adjusted odds ratio (aOR) = 1.68, P  = 0.02]. The Intra-procedural complications were insignificant between the two groups which included bleeding (aOR = 0.72, P  = 0.67), accidental punctures\/lacerations (aOR = 0.77, P  = 0.5), and mechanical ventilation rates (aOR = 1.19, P  = 0.6). Post-ERCP complication rate was similar for bleeding (aOR = 0.72, P  = 0.41) and post-ERCP pancreatitis (aOR = 1.4, P  = 0.44). Frail patients had a longer length of stay (6.7 d vs  5.5 d) and higher mean total charges of hospitalization ($78807 vs  $71392) compared to controls (P  &lt; 0.001). The 30 d all-cause readmission rates between frail and non-frail patients were similar (P  = 0.96).<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>There was a significantly higher mortality risk and healthcare burden amongst nonagenarian frail patients undergoing ERCP compared to non-frail. Larger studies are warranted to investigate and mitigate modifiable risk factors.<\/jats:p>","DOI":"10.4253\/wjge.v16.i3.148","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T03:17:28Z","timestamp":1710386248000},"page":"148-156","source":"Crossref","is-referenced-by-count":12,"title":["Impact of frailty on endoscopic retrograde cholangiopancreatography outcomes in nonagenarians: A United States national experience"],"prefix":"10.4253","volume":"16","author":[{"given":"Sanket Dhirubhai","family":"Basida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dushyant Singh","family":"Dahiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Nadeem","family":"Yousaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brinda","family":"Basida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhanu Siva Mohan","family":"Pinnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manesh Kumar","family":"Gangwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassam","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahib","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yash R","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daksh","family":"Ahluwalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihir Prakash","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Chandan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil R","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,3,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1134-4873"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16362"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2021.09.010"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.04.032"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8992"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-002689"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3182a502dc"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0255122"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1177\/08982643231152694"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.02.022"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.00564"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2015.5085"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28006"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2019.04.057"},{"key":"B15","unstructured":"Healthcare Cost and Utilization Project (HCUP) (2023).   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