{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:40:01Z","timestamp":1784900401274,"version":"3.55.0"},"reference-count":58,"publisher":"Baishideng Publishing Group Inc.","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Endosc"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Routine outpatient endoscopy is performed across a variety of outpatient settings. A known risk of performing endoscopy under moderate sedation is the potential for over-sedation, requiring the use of reversal agents. More needs to be reported on rates of reversal across different outpatient settings. Our academic tertiary care center utilizes a triage tool that directs higher-risk patients to the in-hospital ambulatory procedure center (APC) for their procedure. Here, we report data on outpatient sedation reversal rates for endoscopy performed at an in-hospital APC vs  at a free-standing ambulatory endoscopy digestive health center (AEC-DHC) following risk stratification with a triage tool.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To observe the effect of risk stratification using a triage tool on patient outcomes, primarily sedation reversal events.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>We observed all outpatient endoscopy procedures performed at AEC-DHC and APC from April 2013 to September 2019. Procedures were stratified to their respective sites using a triage tool. We evaluated each procedure for which sedation reversal with flumazenil and naloxone was recorded. Demographics and characteristics recorded include patient age, gender, body mass index (BMI), American Society of Anesthesiologists (ASA) classification, procedure type, and reason for sedation reversal.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>There were 97366 endoscopic procedures performed at AEC-DHC and 22494 at the APC during the study period. Of these, 17 patients at AEC-DHC and 9 at the APC underwent sedation reversals (0.017% vs  0.04%; P  = 0.06). Demographics recorded for those requiring reversal at AEC-DHC vs  APC included mean age (53.5 \u00b1 21 vs  60.4 \u00b1 17.42 years; P  = 0.23), ASA class (1.66 \u00b1 0.48 vs  2.22 \u00b1 0.83; P  = 0.20), BMI (27.7 \u00b1 6.7 kg\/m2 vs  23.7 \u00b1 4.03 kg\/m2; P  = 0.06), and female gender (64.7% vs  22%; P  = 0.04). The mean doses of sedative agents and reversal drugs used at AEC-DHC vs  APC were midazolam (5.9 \u00b1 1.7 mg vs  8.9 \u00b1 3.5 mg; P  = 0.01), fentanyl (147.1 \u00b1 49.9 \u03bcg vs  188.9 \u00b1 74.1 \u03bcg; P  = 0.10), flumazenil (0.3 \u00b1 0.18 \u03bcg vs  0.17 \u00b1 0.17 \u03bcg; P  = 0.13) and naloxone (0.32 \u00b1 0.10 mg vs  0.28 \u00b1 0.12 mg; P  = 0.35). Procedures at AEC-DHC requiring sedation reversal included colonoscopies (n  = 6), esophagogastroduodenoscopy (EGD) (n  = 9) and EGD\/colonoscopies (n  = 2), whereas APC procedures included EGDs (n  = 2), EGD with gastrostomy tube placement (n  = 1), endoscopic retrograde cholangiopancreatography (n  = 2) and endoscopic ultrasound's (n  = 4). The indications for sedation reversal at AEC-DHC included hypoxia (n  = 13; 76%), excessive somnolence (n  = 3; 18%), and hypotension (n  = 1; 6%), whereas, at APC, these included hypoxia (n  = 7; 78%) and hypotension (n  = 2; 22%). No sedation-related deaths or long-term post-sedation reversal adverse outcomes occurred at either site.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>Our study highlights the effectiveness of a triage tool used at our tertiary care hospital for risk stratification in minimizing sedation reversal events during outpatient endoscopy procedures. Using a triage tool for risk stratification, low rates of sedation reversal can be achieved in the ambulatory settings for EGD and colonoscopy.<\/jats:p>","DOI":"10.4253\/wjge.v16.i7.413","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:50:17Z","timestamp":1720399817000},"page":"413-423","source":"Crossref","is-referenced-by-count":4,"title":["Sedation reversal trends at outpatient ambulatory endoscopic center <i>vs<\/i> in-hospital ambulatory procedure center using a triage protocol"],"prefix":"10.4253","volume":"16","author":[{"given":"Saqib","family":"Walayat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stadmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azfar","family":"Hameed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minahil","family":"Sarfaraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Estrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Benson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Soni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Pfau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittney","family":"Kile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Gopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2147\/AMEP.S427076"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.10.017"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2007.08.041"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01561-z"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1055\/a-1236-3814"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2019.0360"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2019.172"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.03.252"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2016.02.001"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000291"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01093.x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-019-03446-0"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.10.021"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2021.11.033"},{"key":"B15","unstructured":"Cullen KA, Hall MJ, Golosinskiy A. 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