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This paper reviews the dynamic expression of Ang-2 in hepatocarcinogenesis and its regulation by hypoxia-inducible factor-1\u03b1. Furthermore, we discuss Ang-2\u2019s potential as an early monitoring biomarker for metastasis, and the therapeutic prospects of silencing hypoxia-inducible factor-1\u03b1 to downregulate Ang-2 and suppress epithelial-mesenchymal transition in HCC treatment.<\/jats:p>","DOI":"10.4254\/wjh.v16.i12.1371","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T04:26:26Z","timestamp":1732854386000},"page":"1371-1376","source":"Crossref","is-referenced-by-count":7,"title":["Targeting hypoxia and angiogenesis in hepatocellular carcinoma: New insights and therapeutic strategies"],"prefix":"10.4254","volume":"16","author":[{"given":"Jia-Yi","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-Ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01332-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2022.13404"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/ph17020195"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2022.0449"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115703"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1082057"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00486"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01432-7"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12010087"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v16.i12.1480"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228689"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-023-02724-y"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/v15010181"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01581-2"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI159473"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30294"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01370-0"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-022-10071-1"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-023-02879-w"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i27.4453"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI150846"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23136934"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s13053-022-00210-8"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-024-03430-1"}],"container-title":["World Journal of Hepatology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v16\/i12\/1371.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v16\/i12\/1371.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T04:26:34Z","timestamp":1732854394000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v16\/i12\/1371.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":25,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.4254\/wjh.v16.i12.1371","relation":{},"ISSN":["1948-5182"],"issn-type":[{"value":"1948-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,27]]}}}