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According to the current guidelines, in the absence of clinically significant portal hypertension, etiological and non-etiological therapies of LC is advisable for the primary preventing gastroesophageal variceal bleeding, whereas its presence serves as an indication for the administration of non-selective \u03b2-blockers, among which carvedilol is the drug of choice. Non-selective \u03b2-blockers, as well as endoscopic variceal ligation and transjugular intrahepatic portosystemic shunt can be used to prevent recurrence of gastroesophageal variceal bleeding. Pharmacotherapy with vasoactive drugs (terlipressin, somatostatin, octreotide), endoscopic variceal ligation, endovascular techniques and transjugular intrahepatic portosystemic shunt are recommended for the treatment of acute gastroesophageal variceal bleeding. Objective and accurate risk stratification of gastroesophageal variceal bleeding will allow developing individual strategies for their prevention and management, avoiding the first and further decompensation in LC, which will improve the prognosis and survival of patients suffering from it.<\/jats:p>","DOI":"10.4254\/wjh.v16.i2.126","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T08:02:33Z","timestamp":1709020953000},"page":"126-134","source":"Crossref","is-referenced-by-count":4,"title":["Contemporary concepts of prevention and management of gastroesophageal variceal bleeding in liver cirrhosis patients"],"prefix":"10.4254","volume":"16","author":[{"given":"Dmitry Victorovich","family":"Garbuzenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.10.020"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.01.018"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.06.018"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.12.022"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-951603"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2018.1506046"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.03.016"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.05.025"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i11.3212"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12407"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.11.033"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.36233\/0507-4088-70"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/CLD.0000000000000015"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s11901-018-0406-x"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v15.i4.525"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.20538\/1682-0363-2022-3-154-165"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i20.6117"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0181"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31875-0"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000342"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.05.050"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.17116\/terarkh2016888101-108"},{"key":"B24","unstructured":"Ivashkin VT, Maevskaya MV, Zharkova MS, Zhigalova SB, Kitsenko EA, Manukyan GV, Trukhmanov AS, Maev IV, Tikhonov IN, Deeva TA. 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