{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:28:00Z","timestamp":1783096080030,"version":"3.54.6"},"reference-count":117,"publisher":"Baishideng Publishing Group Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Hepatol"],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) poses a significant health challenge in modern societies due to shifts in lifestyle and dietary habits. Its complexity stems from genetic predisposition, environmental influences, and metabolic factors. Epigenetic processes govern various cellular functions such as transcription, chromatin structure, and cell division. In NAFLD, these epigenetic tendencies, especially the process of histone methylation, are intricately intertwined with fat accumulation in the liver. Histone methylation is regulated by different enzymes like methyltransferases and demethylases and influences the expression of genes related to adipogenesis. While early-stage NAFLD is reversible, its progression to severe stages becomes almost irreversible. Therefore, early detection and intervention in NAFLD are crucial, and understanding the precise role of histone methylation in the early stages of NAFLD could be vital in halting or potentially reversing the progression of this disease.<\/jats:p>","DOI":"10.4254\/wjh.v16.i5.703","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T05:49:15Z","timestamp":1716356955000},"page":"703-715","source":"Crossref","is-referenced-by-count":6,"title":["Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease"],"prefix":"10.4254","volume":"16","author":[{"given":"Li","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030911"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101111"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811319150009"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e11119"},{"key":"B6","unstructured":"Sharma P, Nandave M, Nandave D, Yadav S, Vargas-De-La-Cruz C, Singh S, Tandon R, Ramniwas S, Behl T. Reactive oxygen species (ROS)-mediated oxidative stress in chronic liver diseases and its mitigation by medicinal plants. Am J Transl Res 2023; 15: 6321-6341"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218138"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6023710"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1119765"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12574"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.863708"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/38444"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.2174\/0929867328666211108105214"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202051803"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25051-2"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2017.09.003"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1798-4"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.02.017"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0237"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061870"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.05.010"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky982"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215083"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1101\/gad.285312.116"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00059"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.154011"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00070-14"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nature12652"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2018.04.016"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.306"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.10.037"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31953-x"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218313"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14617-1"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2009.01326.x"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nature07777"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011085"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.05.019"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04361-y"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00472"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.10.018"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141224154"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228617"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3390\/biology9050093"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.04.004"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-021-00428-7"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04127-6"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1172\/JCI156722"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111703"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1377-1"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2201-1"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.2337\/db20-1110"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3702"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3892\/or.2018.6295"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.07.003"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0009-6"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.03.021"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802800200"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201839"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-021-00753-8"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2021.02.005"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00919-5"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048651"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.02.063"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.24.8.3180-3187.2004"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17676"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.10.002"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810100105"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-311292"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25754"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0186-y"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154939"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22818"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26144"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-016-0311-5"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.10.040"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0811-9"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.03.154"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3390\/biom9120810"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.129"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.103"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1002\/path.4512"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1002\/path.4492"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2514"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15528"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.05.015"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28985"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13102376"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1805662115"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1797-x"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25679"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-013-0253-7"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2303010120"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200706179"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1101\/gad.476008"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.01.028"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15595"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e22589"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-023-01347-8"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102691"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.023"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4036"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2023.147584"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2016.10.004"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-023-01145-z"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-022-00877-5"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61402-7"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1080\/00498254.2018.1490044"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0412-8"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006122"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1038\/nature11262"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2023.102707"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115999"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30145-1"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-3741"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14912"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-12-818948"}],"container-title":["World Journal of Hepatology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v16\/i5\/703.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v16\/i5\/703.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T08:42:08Z","timestamp":1716367328000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v16\/i5\/703.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,27]]},"references-count":117,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4254\/wjh.v16.i5.703","relation":{},"ISSN":["1948-5182"],"issn-type":[{"value":"1948-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,27]]}}}