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Despite these advancements in the clinical handling of hepatitis B, achieving a clinical cure remains elusive for a considerable subset of patients due to the number of challenges that preclude the realization of optimal treatment outcomes. These include, but are not limited to, the emergence of antiviral resistance, incomplete immune recovery, and the persistence of covalently closed circular DNA. Moreover, the variance in response to interferon therapy and the lack of definitive biomarkers for treatment cessation also contribute to the complexity of achieving a clinical cure. This article briefly overviews the current research progress and existing issues in pursuing a clinical cure for hepatitis B.<\/jats:p>","DOI":"10.4254\/wjh.v16.i6.900","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T09:27:50Z","timestamp":1718789270000},"page":"900-911","source":"Crossref","is-referenced-by-count":5,"title":["Hepatitis B cure: Current situation and prospects"],"prefix":"10.4254","volume":"16","author":[{"given":"Ya-Ping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-Suo","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30119-0"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00046-19"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-S4-05"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1159\/000530495"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0702"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.4.323"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2009.02.053"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.11.003"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1007-3418.2019.12.007"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3486-7"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12434"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.11.039"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.01.006"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1007-3418.2019.08.003"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13779"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S195144"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5251-9"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13747-9"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2093847"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i13.1525"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.09.043"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3225"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2020.12.022"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3019"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-019-09956-1"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2017.00072"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30189-3"},{"key":"B28","unstructured":"Lim SG, Yang WL, Chang J, Ngu J, Tan Y, Ahmed T, Dan YY, Lee YM, Lee GH, Tan PS, Phyo WW, Khin LW, Lee C, Tay A, Chan E. 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