{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:59:33Z","timestamp":1792025973934,"version":"4.4.0"},"reference-count":29,"publisher":"Baishideng Publishing Group Inc.","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Hepatol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Acute liver failure (ALF) may be the first and most dramatic presentation of Wilson\u2019s disease (WD). ALF due to WD (WD-ALF) is difficult to distinguish from other causes of liver disease and is a clear indication for liver transplantation. There is no firm recommendation on specific and supportive medical treatment for this condition.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To critically evaluate the diagnostic and therapeutic management of WD-ALF patients in order to improve their survival with native liver.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>A retrospective analysis of patients with WD-ALF was conducted in two pediatric liver units from 2018 to 2023.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>During the study period, 16 children (9 males) received a diagnosis of WD and 2 of them presented with ALF. The first was successfully treated with an unconventional combination of low doses of D-penicillamine and zinc plus steroids, and survived without liver transplant. The second, exclusively treated with supportive therapy, needed a hepatotransplant to overcome ALF.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>Successful treatment of 1 WD-ALF patient with low-dose D-penicillamine and zinc plus steroids may provide new perspectives for management of this condition, which is currently only treated with liver transplantation.<\/jats:p>","DOI":"10.4254\/wjh.v16.i8.1111","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T08:58:47Z","timestamp":1724317127000},"page":"1111-1119","source":"Crossref","is-referenced-by-count":5,"title":["Successful treatment of acute liver failure due to Wilson\u2019s disease: Serendipity or fortuity?"],"prefix":"10.4254","volume":"16","author":[{"given":"Valeria","family":"Delle Cave","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Di Dato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Luigi","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Immacolata","family":"Spagnuolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Iorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50252"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30911"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0018-3"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.07.014"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22446"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.11.007"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.02.057"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/lt.26503"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/children11010068"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32805"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001787"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2018.08.009"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.01.024"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20352"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.11.1377"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.12.051"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2003.00824.x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22322"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2012.03.022"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.5114\/polp.2020.94913"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02158.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.29043"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510x(76)90188-x"},{"key":"B24","doi-asserted-by":"crossref","unstructured":"Sallie R, Katsiyiannakis L, Baldwin D, Davies S, O'Grady J, Mowat A, Mieli-Vergani G, Williams R. 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