{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T02:25:25Z","timestamp":1748312725972,"version":"3.37.3"},"reference-count":22,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Hepatol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Various prognostic scores have been developed to predict mortality and response to steroids in alcoholic hepatitis (AH). We aimed to further validate and compare these scores, particularly pre-day 7 Lille scores, in addition to identifying reliable predictors of complications and mortality such as renal dysfunction and nutritional status.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To identify predictors of complications and mortality in AH, particularly focusing on demographics, renal involvement, underlying liver disease, and nutrition.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>This is a retrospective analysis of patients admitted to a large urban tertiary care center with AH from 2020 to 2022. Receiver operating characteristics (ROC) curve analysis was conducted to compare established prognostic scores with Lille scores from day 3 to day 7 (LM3-7). Logistic regression equations were conducted to identify predictor variables.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>Severe AH (SAH) as defined by Maddrey\u2019s discriminant function \u2265 32 was diagnosed in 150 out of 425 patients with AH. LM3-7 had 28-day mortality rates in the responder group of 7%-11%, while in the non-responder group, mortality rates were approximately 38%-42%. LM3-7 had 90-day mortality rates in the responder group of 12% to 17%, while in the non-responder group, mortality rates were 48%-53%. Furthermore, all LM3-7 scores showed comparable efficacy in predicting mortality using ROC curve analysis; Area under ROC ranged from 0.771 to 0.802 for 28-day mortality and 0.743 to 0.809 for 90-day mortality. Regarding complications and mortality in AH, significant predictors included poor nutritional status, underlying cirrhosis, and acute renal dysfunction.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>LM3-6 is as accurate as LM7 in predicting corticosteroid efficacy for 28-day and 90-day mortality in patients with SAH. Holding glucocorticoids early during the disease course can prevent unnecessary complications.<\/jats:p>","DOI":"10.4254\/wjh.v17.i2.102152","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:51:46Z","timestamp":1740012706000},"source":"Crossref","is-referenced-by-count":1,"title":["Predictors and prognosticators of outcomes in alcoholic hepatitis: A retrospective single center study"],"prefix":"10.4254","volume":"17","author":[{"given":"Kevin","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naren","family":"Nallapeta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nariman","family":"Hossein-Javaheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Quigley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Mahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181fdef1d"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)90401-8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.21037\/tgh.2019.10.02"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.050781"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.09.011"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21607"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.224097"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.539"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112338"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16157"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25328"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90776-9"},{"key":"B13","unstructured":"Lieber CS. 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