{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T05:23:32Z","timestamp":1740029012190,"version":"3.37.3"},"reference-count":135,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Hepatol"],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) is a progressive disease. Without effective interventions, NAFLD can gradually develop to non-alcoholic steatohepatitis, fatty liver fibrosis, liver cirrhosis and even hepatocellular carcinoma. It is still to investigate the precise molecular mechanism behind the pathophysiology of NAFLD. Triggering receptor expressed on myeloid cells 2 (TREM2) can sense tissue injury and mediate immune remodeling, thereby inducing phagocytosis, lipid metabolism, and metabolic transfer, promoting cell survival and combating inflammatory activation. NAFLD might develop as a result of TREM2's regulatory role. We here briefly summarize the biological characteristics of TREM2 and its functions in the disease progression of NAFLD. Moreover, we propose to broaden the therapeutic strategy for NAFLD by targeting TREM2.<\/jats:p>","DOI":"10.4254\/wjh.v17.i2.102328","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:51:46Z","timestamp":1740012706000},"source":"Crossref","is-referenced-by-count":0,"title":["Role of triggering receptor expressed on myeloid cells 2 in the pathogenesis of non-alcoholic fatty liver disease"],"prefix":"10.4254","volume":"17","author":[{"given":"Li-Hui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Tong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Xia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32511-3"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.02.006"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000004"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2022.03.010"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/ATV.0000000000000153"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2024.155835"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309000"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(24)00049-9"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071652"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2021.111438"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0695-9"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00715-5"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306873110"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2007.11.004"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314107"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319227"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/immu.200310033"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0072-1"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1280257"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2023.101739"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2016.1264072"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20391"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2620-14.2015"},{"key":"B25","unstructured":"Hakola HP. Neuropsychiatric and genetic aspects of a new hereditary disease characterized by progressive dementia and lipomembranous polycystic osteodysplasia. Acta Psychiatr Scand Suppl 1972; 1-173"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00247-8"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2020.104878"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.003"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00436-5"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i10.1005"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2017.04.004"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065556"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1086\/342259"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn217"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.517540"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201899456"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.09.034"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201707672"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000265"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32620"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100477"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0424"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3920196"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101122"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23095146"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2021.104441"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-022-00542-y"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.02.008"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415489"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-021-01590-x"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.054"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.907387"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2019.08.004"},{"key":"B54","unstructured":"Dou ZF, Guo YR, Liu JC, Li N, Chai B, Li XQ, Fu R, Wang XJ. Ameliorative effects of glycine in an experimental nonalcoholic steatohepatitis and its correlation between TREM-1 and TREM-2. Am J Transl Res 2016; 284-297"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7144"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102010"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020712"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133177"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10061248"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-021-06208-3"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1172\/JCI135197"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.16417"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01073-0"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30429"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.09.026"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22401"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.10.007"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-2050-9"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.2337\/dbi21-0017"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.2337\/db20-0572"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav3722"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01456-22"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3390\/cells12030341"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00775-1"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03112"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.940867"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.47143"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113164"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.08.002"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110380"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100524"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115528"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154914"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00675-6"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108626"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.07.028"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17842"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.11.013"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000001098"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1460431"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.06.004"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-061020-053707"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00924"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1159\/000518407"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26267"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0009-6"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-016-9339-2"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141679"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.8.1111"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30334"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1503519"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.043"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.04.034"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000312"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2023.0240"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-023-01488-7"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1172\/JCI22675"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.2174\/1389450124666230330135834"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14940"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-023-02002-w"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3877617"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1007-3418.2018.12.008"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15108"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.25589"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abp8309"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1631-3"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12616"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-022-01228-8"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-022-00579-7"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840110114"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14937"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.07.019"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22734"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00381-6"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.08.024"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00754-7"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-018-0115-x"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322638"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.02.032"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.10.079"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27063"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2405746121"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2024.155911"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200785"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00456"}],"container-title":["World Journal of Hepatology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v17\/i2\/102328.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v17\/i2\/102328.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:53:02Z","timestamp":1740012782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v17\/i2\/102328.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,27]]},"references-count":135,"journal-issue":{"issue":"2"},"alternative-id":["102328"],"URL":"https:\/\/doi.org\/10.4254\/wjh.v17.i2.102328","relation":{},"ISSN":["1948-5182"],"issn-type":[{"value":"1948-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,27]]}}}