{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:13:08Z","timestamp":1790302388188,"version":"4.1.0"},"reference-count":34,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Hepatol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Hepatitis B virus (HBV) evades the innate immunity and leads to persistent chronic infection, but the molecular mechanism is still not well known.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To investigate whether HBV-miR-3 is involved in HBV immune evasion.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>HBV-miR-3 agomir and antagomir were employed to verify the effectiveness of HBV-miR-3 on cGAS-Sting-IFN pathway through the experiments on relative luciferase activity, cGAS protein expression, Sting phosphorylation and interferon (IFN) production.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>HBV-miR-3 down-regulates cGAS protein expression post-transcriptionally by inhibition of cGAS 3\u2019-untranslated region (3\u2019-UTR) activity, which results in lower Sting phosphorylation and IFN production. HBV-miR-3 antagomir rescued cGAS protein expression, Sting phosphorylation and IFN-\u03b2 production.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>HBV-miR-3 plays an important role in HBV immunity evasion by targeting cGAS 3\u2019-UTR and interfering with cGAS-Sting-IFN pathway.<\/jats:p>","DOI":"10.4254\/wjh.v17.i2.99292","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:51:46Z","timestamp":1740012706000},"source":"Crossref","is-referenced-by-count":7,"title":["Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling"],"prefix":"10.4254","volume":"17","author":[{"given":"Zhen-Yu","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Shi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Qiang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Zhong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,2,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30056-6"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31902"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20316-8"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.618196"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010204"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.12.042"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01287-2"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116427"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31695"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02267-21"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.10.034"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30054"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-022-01785-3"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S271091"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-52060-0"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01919-16"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004783"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2174\/2211536608666191104105334"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab971"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjz104"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1918971117"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-00884-1"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0416-2016"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22977-5"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-2119"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28966"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000647"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00801-w"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101042R"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00367"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005171"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211838"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.12.018"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.884113"}],"container-title":["World Journal of Hepatology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v17\/i2\/99292.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v17\/i2\/99292.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:52:17Z","timestamp":1740012737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v17\/i2\/99292.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,27]]},"references-count":34,"journal-issue":{"issue":"2"},"alternative-id":["99292"],"URL":"https:\/\/doi.org\/10.4254\/wjh.v17.i2.99292","relation":{},"ISSN":["1948-5182"],"issn-type":[{"value":"1948-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,27]]}}}