{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:59:31Z","timestamp":1784818771398,"version":"3.55.0"},"reference-count":30,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Hepatol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Pyogenic liver abscess (PLA) is increasingly recognized worldwide. In Asia, Klebsiella pneumoniae  (K. pneumoniae ) has emerged as the predominant pathogen, yet contemporary data from Vietnam remain limited.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To determine the microbial spectrum of PLA and compare clinical, computed tomography (CT), management, and outcomes between K. pneumoniae  and non-K. pneumoniae  cases in Southern Vietnam.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>This retrospective cohort included adults with PLA managed at Nhan Dan Gia Dinh Hospital from June 2021 to June 2024. Of 123 cases, 17 were excluded (8 with unspecified Gram-negative bacilli, 9 without CT), leaving 106 patients (83 K. pneumoniae , 23 non-K. pneumoniae ). Data on demographics, comorbidities, presentation, laboratory, imaging, microbiology, treatment, and outcomes were analyzed using standard parametric\/nonparametric and \u03c7 2\/Fisher tests (two-sided \u03b1  = 0.05).<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>Mean age was 59.2 years, and 67.0% were male. Diabetes was more frequent in K. pneumoniae  (55.4% vs  30.4%; P  = 0.034). C-reactive protein was higher in K. pneumoniae  but not significant (229.9 mg\/L vs  185.0 mg\/L; P  = 0.069). Aspartate aminotransferase was significantly elevated (P  = 0.048) and alanine aminotransferase borderline (P  = 0.065). On CT, K. pneumoniae  abscesses more often had irregular margins (P  = 0.038) and heterogeneous architecture (P  = 0.003). K. pneumoniae  predominated in pus (71.9%) and blood (78.6%) cultures. Source-control and hospital stay were similar. Mortality was 10.4% overall, occurring only in K. pneumoniae  (13.3% vs  0%). Older age predicted poorer survival (odds ratio = 0.95; P  = 0.029).<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>In Southern Vietnam, K. pneumoniae  predominates in PLA, characterized by distinctive CT features and higher mortality, emphasizing early recognition, pathogen-directed therapy, and timely image-guided drainage.<\/jats:p>","DOI":"10.4254\/wjh.v18.i2.113695","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T02:36:03Z","timestamp":1770863763000},"source":"Crossref","is-referenced-by-count":1,"title":["<i>Klebsiella pneumoniae<\/i>\n                    as leading cause of pyogenic liver abscess: Three years study in Southern Vietnam"],"prefix":"10.4254","volume":"18","author":[{"given":"Tuong-Anh","family":"Mai-Phan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanh-Phat","family":"Thai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim-Long","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tri-Nhan","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh-Quang","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phu-Cuong","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhu Ngoc-Quynh","family":"Duong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"My-Tran","family":"Trinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen-Khoi","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.614"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2023.2190813"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/s1542-3565(04)00459-8"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14760"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1086\/425616"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/s0732-8893(00)00157-7"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1556\/030.2023.02186"},{"key":"B8","doi-asserted-by":"crossref","unstructured":"Schmoldt A, Benthe HF, Haberland G. 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