{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T03:08:06Z","timestamp":1770865686089,"version":"3.50.1"},"reference-count":56,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Hepatol"],"abstract":"<jats:p>Acrylamide, a contaminant formed during high-temperature cooking of common foods, is increasingly recognized as a silent and underestimated contributor to liver injury. In this editorial, we comment on the study by Nour El Deen et al , demonstrating that a chemically standardized ginger (Zingiber officinale ) extract (\u2265 20% 6-gingerol) mitigates acrylamide-induced hepatotoxicity in rats through antioxidant, anti-inflammatory, and cytoprotective mechanisms. By combining biochemical, histopathological, and molecular evidence, the authors establish a coherent experimental basis for future translational research. Their results are consistent with a growing body of data supporting the hepatoprotective properties of ginger and emphasize the importance of using standardized nutraceutical preparations in preventive hepatology. From a precision-nutrition perspective, ginger phytocompounds appear to influence key oxidative, inflammatory, and metabolic pathways, possibly involving the gut-liver axis. Confirmatory studies in chronic exposure models and human cohorts, together with compositional and protein-level validation, will be essential to strengthen both the mechanistic and translational significance of these findings.<\/jats:p>","DOI":"10.4254\/wjh.v18.i2.114551","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T02:36:03Z","timestamp":1770863763000},"source":"Crossref","is-referenced-by-count":0,"title":["Ginger as a nutraceutical shield: Counteracting acrylamide-induced liver injury"],"prefix":"10.4254","volume":"18","author":[{"given":"Alberto","family":"Massimi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"Massimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/419449a"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1021\/jf030204+"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.142247"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-024-03798-z"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2004.09.008"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2022.0055"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.113696"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2024.101859"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/nu16132032"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-024-09677-1"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-08525-x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118147"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/foods13040556"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1039\/d4ay00466c"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2015.4104"},{"key":"B16","unstructured":"European Union.   Commission Regulation (EU) 2017\/2158 of 20 November 2017 establishing mitigation measures and benchmark levels for the reduction of acrylamide in food (Text with EEA relevance). [cited 3 August 2025]. Available from: https:\/\/eur-lex.europa.eu\/eli\/reg\/2017\/2158\/oj"},{"key":"B17","unstructured":"U.S. Food and Drug Administration.   Guidance for Industry: Acrylamide in foods. [cited 3 August 2025]. Available from: https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/guidance-industry-acrylamide-foods"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106196"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-018-2211-2"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116062"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2173"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2012.10.063"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.10.048"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-024-00306-1"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.576061"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v17.i10.109807"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2015.07.012"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118382"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-58392-1"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076285"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18020631"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508965818"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/foods8060185"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-022-02372-7"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200173"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4405"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201600274"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1400956"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0326690"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.662445"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12112015"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2011.1318"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-016-9423-z"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.779352"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1186\/s40538-023-00385-9"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S234698"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2023.2263788"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1427044"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2021.07.010"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.04.005"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1597599"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfab069"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36858-6"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.21101\/cejph.a6430"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/nu17101657"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i18.2288"}],"container-title":["World Journal of Hepatology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v18\/i2\/114551.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v18\/i2\/114551.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T02:36:43Z","timestamp":1770863803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v18\/i2\/114551.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":56,"journal-issue":{"issue":"2"},"alternative-id":["114551"],"URL":"https:\/\/doi.org\/10.4254\/wjh.v18.i2.114551","relation":{},"ISSN":["1948-5182"],"issn-type":[{"value":"1948-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,27]]}}}