{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T03:08:11Z","timestamp":1770865691130,"version":"3.50.1"},"reference-count":20,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Hepatol"],"abstract":"<jats:p>In this editorial, we comment on the article by Wang et al , which investigates molecular and immune biomarkers predictive of response to sintilimab plus lenvatinib in hepatitis B virus-associated hepatocellular carcinoma (HCC). Yet, despite remarkable progress with immune-checkpoint and anti-angiogenic combinations, the biological heterogeneity of HCC continues to limit durable responses and individualized care. By integrating high-resolution transcriptomic, exomic, and immune-cell-profiling data, Wang et al  identified a coherent triad - elevated LINC01554 expression, enrichment of CD4+ central-memory T cells, and solitary-tumour morphology - that independently predicted prolonged progression-free survival. This constellation links tumour-intrinsic transcriptional restraint, adaptive immune competence, and anatomical containment, illustrating how multi-omic profiling can clarify determinants of therapeutic benefit. These insights signify a shift from empiricism to biologically guided therapy, providing a scaffold for biologic stratification, longitudinal response monitoring, and rational sequencing of immunotherapeutic and anti-angiogenic agents. Collectively, they redefine HCC as a dynamic biological ecosystem rather than a uniform malignancy and highlight the imperative to embed multi-omic biomarker platforms within future clinical-trial design - marking a decisive step toward precision hepatology in inflammation-driven cancers.<\/jats:p>","DOI":"10.4254\/wjh.v18.i2.116475","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T02:36:03Z","timestamp":1770863763000},"source":"Crossref","is-referenced-by-count":0,"title":["Integrating molecular and immune biomarkers for precision therapy in hepatitis B: Associated hepatocellular carcinoma"],"prefix":"10.4254","volume":"18","author":[{"given":"Pranjal","family":"Kashiv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khushboo","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish Ramesh","family":"Balwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek Balkrishna","family":"Kute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v17.i11.112364"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30010-2"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0186-y"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00808"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915745"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1115109"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-1066-z"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30207-1"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061370"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00573-2"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2011-100223"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2484"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1247132"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-3135"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3892\/or.2020.7779"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2014.05.006"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1159\/000516899"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1922-8"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1906-8"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.02.056"}],"container-title":["World Journal of Hepatology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v18\/i2\/116475.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v18\/i2\/116475.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T02:36:59Z","timestamp":1770863819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-5182\/full\/v18\/i2\/116475.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":20,"journal-issue":{"issue":"2"},"alternative-id":["116475"],"URL":"https:\/\/doi.org\/10.4254\/wjh.v18.i2.116475","relation":{},"ISSN":["1948-5182"],"issn-type":[{"value":"1948-5182","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,27]]}}}