{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T03:19:01Z","timestamp":1787541541702,"version":"build-2736575974"},"reference-count":30,"publisher":"The Korean Society of Medical Informatics","issue":"3","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Provincia Autonoma di Trento in the scope of LP","award":["6\/2023"],"award-info":[{"award-number":["6\/2023"]}]}],"content-domain":{"domain":["e-hir.org"],"crossmark-restriction":true},"short-container-title":["Healthc Inform Res"],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:p>Objectives: Inherited retinal dystrophies are characterized by high genetic and phenotypic heterogeneity, and their clinical progression may alternate between latent and active phases. Identifying the onset of the active phase may support earlier intervention for inflammatory retinal degeneration. Plasma proteomics has shown potential for characterizing predictive biomarkers in retinal diseases, but its application remains experimental. This study aimed to develop a methodological simulation exercise to evaluate the performance of machine learning (ML) models in distinguishing active and latent phases using an artificially generated dataset.Methods: An artificial dataset of 500 samples was created, and plasma proteomic profiles were generated for each sample using arbitrary values. Sample classification was based on a pathway activation score. Four ML models were tested: support vector machine, random forest, logistic regression, and extreme gradient boosting. Each model was trained across a range of hyperparameters.Results: Logistic regression achieved the best performance, with an accuracy of 0.73, precision of 0.73, and F1-score of 0.73.Conclusions: This simulation study showed that synthetic proteomic datasets can be used to evaluate ML approaches for distinguishing active and latent phases of retinal dystrophies when real data are scarce. Synthetic data can support the creation of targeted datasets for proteins associated with retinal dystrophies, helping to address the limited availability of suitable open-source data.<\/jats:p>","DOI":"10.4258\/hir.2026.32.3.285","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:52:56Z","timestamp":1786323176000},"page":"285-292","update-policy":"https:\/\/doi.org\/10.4258\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Machine Learning\u2013Based Classification of Active and Latent Phases of Inherited Retinal Dystrophies Using Synthetic Proteomic Data: A Pathway-Based Application Exercise"],"prefix":"10.4258","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7912-5942","authenticated-orcid":true,"given":"Alessandro","family":"Macchia","sequence":"first","affiliation":[{"name":"MAGI'S LAB, Rovereto (TN), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8693-0724","authenticated-orcid":true,"given":"Maria Chiara","family":"Medori","sequence":"additional","affiliation":[{"name":"MAGI'S LAB, Rovereto (TN), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1023-1530","authenticated-orcid":true,"given":"Ahmad Jainul","family":"Abidin","sequence":"additional","affiliation":[{"name":"MAGI'S LAB, Rovereto (TN), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0666-9616","authenticated-orcid":true,"given":"Gabriele","family":"Bonetti","sequence":"additional","affiliation":[{"name":"MAGI'S LAB, Rovereto (TN), Italy"},{"name":"Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5892-6251","authenticated-orcid":true,"given":"Kristjana","family":"Dhuli","sequence":"additional","affiliation":[{"name":"MAGI'S LAB, Rovereto (TN), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9025-058X","authenticated-orcid":true,"given":"Luca","family":"Ferrari","sequence":"additional","affiliation":[{"name":"MAGI EUREGIO, Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8317-066X","authenticated-orcid":true,"given":"Sara","family":"Feizyab","sequence":"additional","affiliation":[{"name":"MAGI EUREGIO, Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9198-620X","authenticated-orcid":true,"given":"Jan","family":"Miertu\u0161","sequence":"additional","affiliation":[{"name":"MAGI'S LAB, Rovereto (TN), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1694-1062","authenticated-orcid":true,"given":"Benedetto","family":"Falsini","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. 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