{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:24:32Z","timestamp":1773282272870,"version":"3.50.1"},"reference-count":22,"publisher":"The Society for Antibacterial and Antifungal Agents, Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biocontrol Sci."],"published-print":{"date-parts":[[2012]]},"DOI":"10.4265\/bio.17.93","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T22:39:29Z","timestamp":1340836769000},"page":"93-99","source":"Crossref","is-referenced-by-count":24,"title":["In vitro Assessment of the Cytotoxicity of Six Topical Antibiotics to Four Cultured Ocular Surface Cell Lines"],"prefix":"10.4265","volume":"17","author":[{"given":"MASAHIKO","family":"AYAKI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ATSUO","family":"IWASAWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOSHIMI","family":"NIWANO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2789","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Arata, J., Horio, T., Soejima, R., and Ohara, K. (1998) Photosensitivity reactions caused by lomefloxacin hydrochloride: a multicenter survey. <I>Antimicrob. Agents Chemother<\/I>., <B>42<\/B>, 3141-3145.","DOI":"10.1128\/AAC.42.12.3141"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Ayaki, M., Iwasawa, A., and Inoue, Y. (2010a) Toxicity to human corneal endothelial cells of major antiglaucoma medications with and without benzalkonium chloride. <I>Clinical Ophthalmology<\/I>, <B>4<\/B>, 1217-1222.","DOI":"10.2147\/OPTH.S13708"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4265\/bio.15.97"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Ayaki, M., Iwasawa, A., and Niwano, Y. (2011) Cytotoxicity assays of new artificial tears containing 2-methacryloyloxyethyl phosphorylcholine polymer for ocular surface cells. <I>Jpn. J. Ophthalmol<\/I>. Aug 10 2011 Epub ahead of print. <B>55<\/B>, 541-546.","DOI":"10.1007\/s10384-011-0073-8"},{"key":"5","unstructured":"Ayaki, M., and Iwasawa, A. (2011a) Critical concentration of benzalkonium chloride in eye drop for toxicity in cultured ocular surface cell lines. <I>Inv. Ophthalmol. Vis. Sci<\/I>., <B>52<\/B>, E-Abstract 1955."},{"key":"6","unstructured":"Ayaki, M., and Iwasawa, A. (2011b) Cytotoxicity of pinorexine and cianocobaramine ophthalmic solutions for four cultured corneal and conjunctival cell lines. <I>Folia Japonica de Ophthalmologica Clinica<\/I>, <B>4<\/B>, 872-875 (in Japanese) ."},{"key":"7","doi-asserted-by":"crossref","unstructured":"Bai, T., Huang, J., and Wang, W. (2010) Short-term comparative study of the effects of preserved and unpreserved topical levofloxacin on the human ocular surface. <I>Cutan. Ocul. Toxicol<\/I>., <B>29<\/B>, 247-53.","DOI":"10.3109\/15569527.2010.492488"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Bezwada, P., Clarck, L.A., and Schnider, S. (2008) Intrinsic cytotoxic effects of fluoroquinolones on human corneal keratocytes and endothelial cells. <I>Current Medical Research and Option<\/I>, <B>24<\/B>, 419-424.","DOI":"10.1185\/030079908X261005"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Domagala, J.M. (1994) Structure-activity and structure-side-effect relationships for the quinolone antibacterials. <I>J. Antimicrob. Chemother<\/I>., <B>33<\/B>, 685-706.","DOI":"10.1093\/jac\/33.4.685"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Dutot, M., Pouzaud, F., Larosche, I., Brignole-Baudouin, F., Warnet, J.M., and Rat, P. (2006) Fluoroquinolone eye drop-induced cytotoxicity: role of preservative in P2X7 cell death receptor activation and apoptosis. <I>Invest. Ophthalmol. Vis. Sci<\/I>., <B>47<\/B>, 2812-2819.","DOI":"10.1167\/iovs.06-0224"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.02.032"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Gangopadhyay, N., Daniell, M., Weih, L., and Taylor, H.R. (2000) Fluoroquinolone and fortified antibiotics for treating bacterial corneal ulcers. <I>Br. J. Ophthalmol<\/I>., <B>84<\/B>, 378-384.","DOI":"10.1136\/bjo.84.4.378"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00369-9"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Kim, S.Y., Lim, J.A., Choi, J.S., Choi, E.C., and Joo, C.K. (2007) Comparison of antibiotic effect and corneal epithelial toxicity of levofloxacin and moxifloxacin in vitro. <I>Cornea<\/I>, <B>26<\/B>, 720-725.","DOI":"10.1097\/ICO.0b013e3180515251"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Lawrence, L.E., Wu, P., Fan. L., Gouveia, K.E., Card, A., Casperson, M., Denbleyker. K., and Barrett, J.F. (2001) The inhibition and selectivity of bacterial topoisomerases by BMS-284756 and its analogues. <I>J. Antimicrob. Chemother<\/I>., <B>48<\/B>, 195-201.","DOI":"10.1093\/jac\/48.2.195"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Leonardi, A., Papa, V., Fregona, I., Russo, P., De Franchis, G., and Milazzo, G. (2006) In vitro effects of fluoroquinolone and aminoglycoside antibiotics on human keratocytes. <I>Cornea<\/I>, <B>25<\/B>, 85-90.","DOI":"10.1097\/01.ico.0000164782.10667.ed"},{"key":"17","doi-asserted-by":"crossref","unstructured":"Mallari, P.L., McCarty, D.J., Daniell, M., and Taylor, H. (2001) Increased incidence of corneal perforation after topical fluoroquinolone treatment for microbial keratitis. <I>Am. J. Ophthalmol<\/I>., <B>131<\/B>, 131-133.","DOI":"10.1016\/S0002-9394(00)00642-5"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2000.d01-16.x"},{"key":"19","unstructured":"Sakurai, M., Hatou, S., and Mochizuki, H. (2006) In vitro effects of fluoroquinolones on corneal epithelial cells and keratocytes. <I>Atarashii Ganka<\/I>., <B>23<\/B>, 1209-1212."},{"key":"20","doi-asserted-by":"crossref","unstructured":"Sharma, C., Velpandian, T., Baskar, Singh S., Ranjan, Biswas N., Bihari, Vajpayee R., and Ghose, S. (2011) Effect of fluoroquinolones on the expression of matrix metalloproteinase in debrided cornea of rats. <I>Toxicol. Mech. Methods<\/I>., <B>21<\/B>. 6-12.","DOI":"10.3109\/15376516.2010.529183"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Sosa, A.B., Epstein, S.P., and Asbell, P.A. (2008) Evaluation of toxicity of commercial ophthalmic fluoroquinolone antibiotics as assessed on immortalized corneal and conjunctival epithelial cells. <I>Cornea<\/I>, <B>27<\/B>, 930-934.","DOI":"10.1097\/ICO.0b013e31816f27ab"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Walter, K. and Tyler, M.E. (2006) Severe corneal toxicity after topical fluoroquinolone therapy: report of two cases. <I>Cornea<\/I>, <B>25<\/B>, 855-857.","DOI":"10.1097\/01.ico.0000224642.43601.14"}],"container-title":["Biocontrol Science"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T19:36:16Z","timestamp":1621539376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bio\/17\/2\/17_93\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.4265\/bio.17.93","relation":{},"ISSN":["1342-4815","1884-0205"],"issn-type":[{"value":"1342-4815","type":"print"},{"value":"1884-0205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}