{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T18:14:35Z","timestamp":1764785675093,"version":"3.44.0"},"reference-count":28,"publisher":"The Korean Society of Critical Care Medicine","issue":"3","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["accjournal.org"],"crossmark-restriction":true},"short-container-title":["ACC"],"published-print":{"date-parts":[[2025,8,31]]},"abstract":"<jats:p>Background: The administration of high-dose vitamins has been focused on in critically ill patients as adjunctive therapy for life-threatening conditions. We evaluated the association between serum vitamin C concentrations and patient prognosis. Methods: We retrospectively reviewed and collected clinical and biochemical data, including thiamine and vitamin C levels, of patients admitted to the pediatric intensive care unit (PICU). Results: In total, 177 patients were admitted to the PICU during the study period, and 63 children were enrolled in this study. The most common reason for PICU admission was sepsis (33.3%). The median thiamine and vitamin C levels were 3.6 \u00b5g\/dl (interquartile range [IQR], 2.9\u20134.5 \u00b5g\/dl) and 2.84 \u00b5g\/ml (IQR, 1.61\u20134.55 \u00b5g\/ml), respectively. Thiamine deficiency was observed in 10 patients (15.9%), and 17 (27.0%) had vitamin C deficiency. There were no differences in the vitamin levels according to the reason for PICU admission. Vitamin C levels were affected by nutritional status. The length of stay in the PICU and duration of mechanical ventilation were longer in patients with vitamin C deficiency than in those without (P=0.035 and P=0.010, respectively). The serum delta neutrophil index and C-reactive protein and lactate levels increased in the vitamin C-deficient group (P=0.028 and P=0.039, respectively). There was a significant difference in Pediatric Index of Mortality 3 scores according to vitamin C levels but not in mortality directly.Conclusions: Vitamin C deficiency was associated with elevated inflammatory marker levels, increased mechanical ventilation durations, and PICU admission. Our results support the potential benefits of vitamin C administration in critically ill children. <\/jats:p>","DOI":"10.4266\/acc.000975","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T01:41:21Z","timestamp":1756431681000},"page":"482-490","update-policy":"https:\/\/doi.org\/10.4266\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low vitamin C concentrations and prognosis in critically ill children"],"prefix":"10.4266","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5634-9709","authenticated-orcid":true,"given":"Min Jung","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6045-9927","authenticated-orcid":true,"given":"Yoon Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4965-6193","authenticated-orcid":true,"given":"Soo Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4266-5655","authenticated-orcid":true,"given":"Jong Deok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4342-6143","authenticated-orcid":true,"given":"Mireu","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0601-7300","authenticated-orcid":true,"given":"Hamin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-487X","authenticated-orcid":true,"given":"Myung Hyun","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4529-6135","authenticated-orcid":true,"given":"Kyung Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2790","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1017\/s0954422418000124"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4266\/acc.2022.01088"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2017.11.020"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000003700"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5107-y"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8010102"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010193"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172889"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01673-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/pcc.0000000000003349"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/pcc.0000000000002074"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/nu12072008"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(07)61690-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29786"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.11195"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.2421"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06288-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/nu14091862"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2018.10.009"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.11.036"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/mcc.0000000000001062"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35796-4"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0928-0"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1177\/0885066619854355"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.4266\/acc.2018.00150"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.09.031"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040708"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/mcc.0000000000000622"}],"container-title":["Acute and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/accjournal.org\/upload\/pdf\/acc-000975.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/accjournal.org\/journal\/view.php?doi=10.4266\/acc.000975","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/accjournal.org\/upload\/pdf\/acc-000975.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T01:44:39Z","timestamp":1756431879000},"score":1,"resource":{"primary":{"URL":"http:\/\/accjournal.org\/journal\/view.php?doi=10.4266\/acc.000975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,31]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,8]]}},"URL":"https:\/\/doi.org\/10.4266\/acc.000975","relation":{},"ISSN":["2586-6052","2586-6060"],"issn-type":[{"value":"2586-6052","type":"print"},{"value":"2586-6060","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,31]]},"assertion":[{"value":"2025-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-29","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-31","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}