{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:13:24Z","timestamp":1788509604254,"version":"build-2803163510"},"reference-count":16,"publisher":"The Korean Society of Critical Care Medicine","issue":"3","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["accjournal.org"],"crossmark-restriction":true},"short-container-title":["ACC"],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:p>Background: Venovenous (VV) extracorporeal membrane oxygenation (ECMO) supports pediatric patients with severe respiratory failure; however, some experience clinical deterioration requiring conversion to venoarterial (VA) ECMO or resulting in mortality. The prognostic role of the vasoactive-inotropic score (VIS) at VV ECMO cannulation remains unclear.Methods: We retrospectively analyzed pediatric patients who underwent VV ECMO between 2010 and 2024 at a single center. Baseline VIS was calculated from vasoactive infusion rates documented immediately prior to cannulation. The primary composite outcome was conversion to VA ECMO or in-hospital mortality. Associations between VIS and outcomes were assessed using correlation, univariable logistic regression, and receiver operating characteristic (ROC) analysis.Results: Twenty patients underwent VV ECMO. Five (25.0%) required VA conversion, seven (35.0%) died, and nine (45.0%) met the composite outcome. Baseline VIS was not significantly associated with isolated mode change (r=0.13, P=0.589) and showed a borderline association with mortality (r=0.43, P=0.062). Logistic regression demonstrated a consistent direction of association between higher baseline VIS and the composite outcome (odds ratio, 1.04; 95% CI, 1.00\u20131.09; P=0.078). Correlation analysis also suggested an association (r=0.54, P=0.014). ROC analysis demonstrated an AUC of 0.79, suggesting potential discriminative ability, with an exploratory cutoff of 25.Conclusions: Baseline VIS showed a possible association with clinical deterioration in this pilot cohort. These findings are exploratory and require validation in larger prospective multicenter studies.<\/jats:p>","DOI":"10.4266\/acc.008840","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:50:16Z","timestamp":1787118616000},"page":"654-660","update-policy":"https:\/\/doi.org\/10.4266\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vasoactive-inotropic score as a predictor of clinical deterioration in pediatric patients undergoing venovenous extracorporeal membrane oxygenation: a preliminary single-center study in South Korea"],"prefix":"10.4266","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2088-4029","authenticated-orcid":true,"given":"Joung-Hee","family":"Byun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8332-5200","authenticated-orcid":true,"given":"Young A","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7349-2841","authenticated-orcid":true,"given":"Hye Jin","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3972-456X","authenticated-orcid":true,"given":"Hyungtae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-1391","authenticated-orcid":true,"given":"Jae Hong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4407-2746","authenticated-orcid":true,"given":"Kwang Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2790","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/mat.0000000000001223"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2013.11.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/pcc.0b013e3181b806fc"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2544-x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/pcc.0000000000001191"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-021-03846-x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11092390"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.769932"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-023-02403-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.07.029"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000003325"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4103\/jpcc.jpcc_65_23"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4266\/acc.2019.00584"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.09.117"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(10)62226-x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000266"}],"container-title":["Acute and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/accjournal.org\/upload\/pdf\/acc-008840.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/accjournal.org\/journal\/view.php?doi=10.4266\/acc.008840","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/accjournal.org\/upload\/pdf\/acc-008840.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:29:20Z","timestamp":1788506960000},"score":1,"resource":{"primary":{"URL":"http:\/\/accjournal.org\/journal\/view.php?doi=10.4266\/acc.008840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,8]]}},"URL":"https:\/\/doi.org\/10.4266\/acc.008840","relation":{},"ISSN":["2586-6052","2586-6060"],"issn-type":[{"value":"2586-6052","type":"print"},{"value":"2586-6060","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"2025-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}