{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:57:33Z","timestamp":1791946653286,"version":"4.3.4"},"reference-count":33,"publisher":"The Korean Society of Critical Care Medicine","issue":"1","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["accjournal.org"],"crossmark-restriction":true},"short-container-title":["Acute Crit Care"],"published-print":{"date-parts":[[2022,2,28]]},"abstract":"<jats:p>Background: Nosocomial meningitis is a medical emergency that requires early diagnosis, prompt initiation of therapy, and frequent admission to the intensive care unit (ICU).Methods: A retrospective study was conducted in adult patients diagnosed with nosocomial meningitis who required admission to the ICU between April 2010 and March 2020. Meningitis\/ventriculitis and intracranial infection were defined according to Centers for Disease Control and Prevention guidelines.Results: An incidence of 0.75% of nosocomial meningitis was observed among 70 patients. The mean patient age was 59 years and 34% were \u226565 years. Twenty-two percent of patients were in an immunocompromised state. A clear predisposing factor for nosocomial meningitis (traumatic brain injury, basal skull fracture, brain hemorrhage, central nervous system [CNS] invasive procedure or device) was present in 93% of patients. Fever was the most frequent clinical feature. A microbiological agent was identified in 30% of cases, of which 27% were bacteria, with a predominance of Gram-negative over Gram-positive. Complications developed in 47% of cases, 24% of patients were discharged with a Glasgow coma scale &lt;14, and 37% died. No clinical predictor of complications was identified. Advanced age (\u226565 years old) and presence of complications were associated with higher hospital mortality. Conclusions: Nosocomial meningitis in intensive care has a low incidence rate but high mortality and morbidity. In a critical care patient with CNS-related risk factors, a high level of suspicion for meningitis must be employed, but diagnosis is hindered by several confounding factors.<\/jats:p>","DOI":"10.4266\/acc.2021.01151","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T07:54:41Z","timestamp":1643183681000},"page":"61-70","update-policy":"https:\/\/doi.org\/10.4266\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Nosocomial meningitis in intensive care: a 10-year retrospective study and literature review"],"prefix":"10.4266","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4283-7549","authenticated-orcid":true,"given":"Sofia 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