{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:24:38Z","timestamp":1792466678902,"version":"4.5.0"},"reference-count":66,"publisher":"The Korean Society of Critical Care Medicine","issue":"1","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["accjournal.org"],"crossmark-restriction":true},"short-container-title":["Acute Crit Care"],"published-print":{"date-parts":[[2022,2,28]]},"abstract":"<jats:p>The brain-lung interaction can seriously affect patients with traumatic brain injury, triggering a vicious cycle that worsens patient prognosis. Although the mechanisms of the interaction are not fully elucidated, several hypotheses, notably the \u201cblast injury\u201d theory or \u201cdouble hit\u201d model, have been proposed and constitute the basis of its development and progression. The brain and lungs strongly interact via complex pathways from the brain to the lungs but also from the lungs to the brain. The main pulmonary disorders that occur after brain injuries are neurogenic pulmonary edema, acute respiratory distress syndrome, and ventilator-associated pneumonia, and the principal brain disorders after lung injuries include brain hypoxia and intracranial hypertension. All of these conditions are key considerations for management therapies after traumatic brain injury and need exceptional case-by-case monitoring to avoid neurological or pulmonary complications. This review aims to describe the history, pathophysiology, risk factors, characteristics, and complications of brain-lung and lung-brain interactions and the impact of different old and recent modalities of treatment in the context of traumatic brain injury.<\/jats:p>","DOI":"10.4266\/acc.2021.01193","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T02:01:36Z","timestamp":1644804096000},"page":"35-44","update-policy":"https:\/\/doi.org\/10.4266\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Brain-lung interaction: a vicious cycle in traumatic brain injury"],"prefix":"10.4266","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2005-5781","authenticated-orcid":true,"given":"Ariana Alejandra","family":"Chac\u00f3n-Aponte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0896-0869","authenticated-orcid":true,"given":"\u00c9rika Andrea","family":"Dur\u00e1n-Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-3616","authenticated-orcid":true,"given":"Jaime Adolfo","family":"Ar\u00e9valo-Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1960-7334","authenticated-orcid":true,"given":"Iv\u00e1n David","family":"Lozada-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8962-6947","authenticated-orcid":true,"given":"Maria Paz","family":"Bola\u00f1o-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4180-6962","authenticated-orcid":true,"given":"Luis Rafael","family":"Moscote-Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2099-4378","authenticated-orcid":true,"given":"Pedro","family":"Grille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5852-0090","authenticated-orcid":true,"given":"Tariq","family":"Janjua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2790","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(17)30362-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs5.50243"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/207247"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5492\/wjccm.v4.i3.163"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(02)77750-7"},{"key":"ref6","first-page":"39","volume-title":"Respiratory insufficiency in combat casualties. 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