{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:51:35Z","timestamp":1787755895048,"version":"build-2784847793"},"reference-count":18,"publisher":"The Korean Society of Critical Care Medicine","issue":"4","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["accjournal.org"],"crossmark-restriction":true},"short-container-title":["Acute Crit Care"],"published-print":{"date-parts":[[2022,11,30]]},"abstract":"<jats:p>Background: Studies on the effects of viral coinfection on bacterial pneumonia are still scarce in South Korea. This study investigates the frequency and seasonal distribution of virus infection and its impact on the prognosis in patients with community-acquired pneumonia (CAP).Methods: The medical records of CAP patients with definite etiology, such as viruses and bacteria, were retrospectively reviewed. Their epidemiologic and clinical characteristics, microbiologic test results, the severity of illness, and 30-day mortality were analyzed.Results: Among 150 study subjects, 68 patients (45.3%) had virus infection alone, 47 (31.3%) had bacterial infection alone, and 35 (23.3%) had viral-bacterial coinfection, respectively. Among 103 patients with viral infections, Influenza A virus (44%) was the most common virus, followed by rhinovirus (19%), influenza B (13%), and adenovirus (6%). The CURB-65 score of the viral-bacterial coinfection was higher than that of the viral infection (median [interquartile range]: 2.0 [1.0\u20134.0] vs. 2.0 [0.3\u20133.0], P=0.029). The 30-day mortality of the viral infection alone group (2.9%) was significantly lower than that of bacterial infection alone (19.1%) and viral-bacterial coinfection (25.7%) groups (Bonferroni-corrected P&lt;0.05). Viral-bacterial coinfection was the stronger predictor of 30-day mortality in CAP (odds ratio [OR], 18.9; 95% confidence interval [CI], 3.0\u2013118.3; P=0.002] than bacterial infection alone (OR, 6.3; 95% CI, 1.1\u201336.4; P=0.041), compared to viral infection alone on the multivariate analysis. Conclusions: The etiology of viral infection in CAP is different according to regional characteristics. Viral-bacterial coinfection showed a worse prognosis than bacterial infection alone in patients with CAP.<\/jats:p>","DOI":"10.4266\/acc.2022.00682","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T07:16:01Z","timestamp":1665040561000},"page":"550-560","update-policy":"https:\/\/doi.org\/10.4266\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The frequency and seasonal distribution of viral infection in patients with community-acquired pneumonia and its impact on the prognosis"],"prefix":"10.4266","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5673-6231","authenticated-orcid":true,"given":"Kyung Jun","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3567-4254","authenticated-orcid":true,"given":"Doh Hyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2790","reference":[{"key":"ref1","volume-title":"","author":"Jameson","year":"2018"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2014.29.6.735"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5124\/jkma.2020.63.5.286"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.03.003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcp1214869"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.46.6364"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2017.58.1.180"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201112-2240oc"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1500245"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2010.42.6.397"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2013.28.6.888"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114710"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1086\/600870"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2017.06.002"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.123158"},{"key":"ref16","first-page":"7","volume-title":"Factors that may impact on immunosenescence: an appraisal","author":"Ongradi","year":"2010"},{"key":"ref17","first-page":"13347","volume-title":"Defective respiration and one-carbon metabolism contribute to impaired naive T cell activation in aged mice","author":"Ron-Harel","year":"2018"},{"key":"ref18","first-page":"595","volume-title":"T cell ageing: effects of age on development, survival &amp; function","author":"Salam","year":"2013"}],"container-title":["Acute and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/accjournal.org\/upload\/pdf\/acc-2022-00682.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/accjournal.org\/journal\/view.php?doi=10.4266\/acc.2022.00682","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/accjournal.org\/upload\/pdf\/acc-2022-00682.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T07:37:18Z","timestamp":1669793838000},"score":1,"resource":{"primary":{"URL":"http:\/\/accjournal.org\/journal\/view.php?doi=10.4266\/acc.2022.00682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,30]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,11]]}},"URL":"https:\/\/doi.org\/10.4266\/acc.2022.00682","relation":{},"ISSN":["2586-6052","2586-6060"],"issn-type":[{"value":"2586-6052","type":"print"},{"value":"2586-6060","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,30]]},"assertion":[{"value":"2022-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-06","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-30","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}