{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:45:57Z","timestamp":1788201957611,"version":"build-2803163510"},"reference-count":23,"publisher":"The Korean Society of Critical Care Medicine","issue":"4","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["accjournal.org"],"crossmark-restriction":true},"short-container-title":["ACC"],"published-print":{"date-parts":[[2023,11,30]]},"abstract":"<jats:p>Background: The use of biomarkers to predict patient outcomes may be crucial for patients admitted to the intensive care unit (ICU) following surgery because biomarkers guide clinicians in tailoring treatment plans accordingly. Therefore, we aimed to identify potential biomarkers to predict the prognosis of patients with Fournier\u2019s gangrene (FG) admitted to the ICU after surgery.Methods: We enrolled patients with FG admitted to our Hospital between January 2013 and December 2022. We retrospectively analyzed patient characteristics, factors related to management, scores known to be associated with the prognosis of FG, and laboratory data.Results: The study population included 28 survivors and 13 nonsurvivors. The initial serum lactate level taken in the emergency department; white blood cell, neutrophil, and platelet counts; delta neutrophil index and international normalized ratio; albumin, glucose, HCO3, and postoperative lactate levels; and the laboratory risk indicator for necrotizing fasciitis differed between survivors and nonsurvivors. Postoperative lactate and initial albumin levels were independent predictors of mortality in patients with FG. In the receiver operating characteristic curve analysis, the postoperative lactate level was the best indicator of mortality (area under the curve, 0.877; 95% confidence interval, 0.711\u20131.000). The optimal cutoff postoperative lactate level for predicting mortality was 3.0 mmol\/L (sensitivity, 80.0%; specificity, 95.0%).Conclusions: Postoperative lactate and initial albumin levels could be potential predictors of mortality in patients with FG admitted to the ICU after surgery, and the optimal cutoff postoperative lactate and initial albumin levels to predict mortality were 3.0 mmol\/L and 3.05 g\/dl, respectively. Large-scale multicenter prospective studies are required to confirm our results.<\/jats:p>","DOI":"10.4266\/acc.2023.00766","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T06:23:05Z","timestamp":1700547785000},"page":"452-459","update-policy":"https:\/\/doi.org\/10.4266\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Biomarkers to predict mortality in patients with Fournier\u2019s gangrene admitted to the intensive care unit after surgery in South Korea"],"prefix":"10.4266","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1005-7233","authenticated-orcid":true,"given":"In Sik","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9685-5924","authenticated-orcid":true,"given":"Seong 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