{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:03:03Z","timestamp":1792857783891,"version":"4.5.0"},"reference-count":30,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,3]]},"abstract":"<jats:p>Although increases in severity of mortality from dengue infection have been observed in Brazil, their determinants are not fully known. A case\u2013control study was conducted by using the National Notifiable Diseases Surveillance System, including patients with severe dengue during 2000\u20132005. Cases were defined as patients that died and controls were those who survived. Hierarchical multivariate logistic regression was performed. During the study period, there were 12,321 severe cases of dengue and 1,062 deaths. Factors independently associated with death included age \u2265 50 years (odds ratio [OR] = 2.29, 95% confidence interval [CI] = 1.59\u20133.29), &lt; 4 years of schooling (OR = 1.83, 95% CI = 1.47\u20132.28), a rural area (OR =2.84, 95% CI = 2.19\u20133.69), hospitalization (OR = 1.42, 95% CI = 1.17\u20131.73), and a high hematocrit (OR = 2.46, 95% CI = 1.85\u20133.28). Factors associated with a lower chance of dying were female sex (OR = 0.76, 95% CI = 0.67\u20130.87), history of previous dengue (OR = 0.78, 95% CI = 0.62\u20130.99), positive tourniquet test result (OR = 0.47, 95% CI = 0.33\u20130.66), laboratory diagnosis of dengue (OR = 0.75, 95% CI = 0.61\u20130.92), and a platelet count of 50,000\u2013100,000 cells\/mm<jats:sup>3<\/jats:sup> (OR = 0.56, 95% CI = 0.36\u20130.87). The risk profile identified in this study should serve to direct public health interventions to minimize deaths.<\/jats:p>","DOI":"10.4269\/ajtmh.11-0774","type":"journal-article","created":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T03:25:59Z","timestamp":1360639559000},"page":"670-676","source":"Crossref","is-referenced-by-count":93,"title":["Determinants of Mortality from Severe Dengue in Brazil: A Population-Based Case-Control Study"],"prefix":"10.4269","volume":"88","author":[{"given":"Giselle Hentzy","family":"Moraes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane","family":"de F\u00e1tima Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth Carmen","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Curr Opin Immunol","first-page":"391","article-title":"Dengue vaccines: progress and challenges","volume":"23","author":"Coller","year":"2011"},{"key":"R2","series-title":"Am J Trop Med Hyg","first-page":"781","article-title":"Classification of dengue illness based on readily available laboratory data","volume":"83","author":"Potts","year":"2010"},{"key":"R3","series-title":"Neglected Tropical Diseases","first-page":"1","article-title":"Best practices in dengue surveillance: a report from the Asia-Pacific and Americas Dengue Prevention Boards","volume":"4","author":"Beatty","year":"2010"},{"key":"R4","series-title":"Dengue Hemorrhagic Fever: Diagnosis, Treatment, Prevention and Control","author":"World Health Organization","year":"1997"},{"key":"R5","series-title":"Rev Cubana Med Trop","first-page":"171","article-title":"Dengue hemorrhagic fever: two infections and antibody dependent enhancement: a brief history and personal memoir","volume":"54","author":"Halstead","year":"2002"},{"key":"R6","series-title":"Am J Epidemiol","first-page":"653","article-title":"Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong. Thailand. I. The 1980 outbreak","volume":"120","author":"Sangkawibha","year":"1984"},{"key":"R7","series-title":"Trans R Soc Trop Med Hyg","first-page":"816","article-title":"Why dengue hemorrhagic fever in Cuba? Individual risk factors for dengue hemorrhagic fever\/dengue shock syndrome (DHF\/DSS)","volume":"81","author":"Bravo","year":"1987"},{"key":"R8","series-title":"Arch Virol","first-page":"533","article-title":"Race: a risk factor for dengue hemorrhagic fever","volume":"152","author":"de la","year":"2007"},{"key":"R9","series-title":"Trop Med Int Health","first-page":"1022","article-title":"Risk factors and clinical features associated with severe dengue infection in adults and children during 2001 epidemic in Chonburi, Thailand","volume":"9","author":"Wichmann","year":"2004"},{"key":"R10","series-title":"Report of the Meeting of the Scientific Working Group on Dengue","first-page":"1","author":"World Health Organization","year":"2006"},{"key":"R11","series-title":"J Infect Dis","first-page":"817","article-title":"Dengue and dengue hemorrhagic fever among adults: clinical outcomes related to viremia, serotypes, and antibody response","volume":"197","author":"Guilarde","year":"2008"},{"key":"R12","series-title":"Emerg Infect Dis","first-page":"48","article-title":"Dengue and dengue hemorrhagic fever, Brazil, 1981\u20132002","volume":"11","author":"Siqueira","year":"2005"},{"key":"R13","series-title":"Trends Microbiol","first-page":"100","article-title":"Epidemic dengue\/dengue hemorrhagic fever as a public health. social and economic problem in the 21st century","volume":"10","author":"Gubler","year":"2002"},{"key":"R14","series-title":"Proc Natl Acad Sci USA","first-page":"2395","article-title":"Dengue: the risk to develop and developing countries","volume":"91","author":"Monath","year":"1994"},{"key":"R15","series-title":"Number of Reported Cases of Dengue and Dengue Hemorrhagic Fever (DHF). Region of the Americas","author":"Pan American Health Organization","year":"2007"},{"key":"R16","series-title":"J Epidemiol Community Health","first-page":"233","article-title":"Associated factors with deaths among pulmonary tuberculosis patients: a case-control study with secondary data","volume":"63","author":"Duarte","year":"2009"},{"key":"R17","series-title":"Logistic Regression: A Self-Learning Text","author":"Kleinbaum","year":"1994"},{"key":"R18","series-title":"Epidemiol Serv Sa\u00fade","first-page":"233","article-title":"List of avoidable causes of deaths due to interventions of the Brazilian Health System [in Portuguese]","volume":"16","author":"Malta","year":"2007"},{"key":"R19","series-title":"Am J Trop Med Hyg","first-page":"149","article-title":"Clinical and laboratory characteristics and risk factors for fatality in elderly patients with dengue hemorrhagic fever","volume":"79","author":"Lee","year":"2008"},{"key":"R20","series-title":"Rev Panam Salud Publica\/Pan Am J Public Health","first-page":"362","article-title":"Dengue severity in elderly in Puerto Rico","volume":"13","author":"Garc\u00eda-Riveira","year":"2003"},{"key":"R21","series-title":"Rev Panam Salud Publica\/Pan Am J Public Health","first-page":"365","article-title":"Utilization of health care services in Brazil: gender. family characteristics and social status","volume":"11","author":"Travassos","year":"2002"},{"key":"R22","series-title":"Brazil Health 2007: An Analysis of the Health Situation [in Portuguese]","author":"Brazil","year":"2008"},{"key":"R23","series-title":"Study and Research No. 19. Synthesis of Social Indicators [in Portuguese]","author":"Brazil","year":"2006"},{"key":"R24","series-title":"Lancet Infect Dis","first-page":"297","article-title":"Severe dengue: the need for new case definitions. Personal view","volume":"6","author":"Rigau-P\u00e9rez","year":"2006"},{"key":"R25","series-title":"Dengue Bull","first-page":"114","article-title":"Improvement of case-management: a key factor to reduce case fatality rate of dengue hemorrhagic fever in the southern Vietnam","volume":"27","author":"Hung","year":"2003"},{"key":"R26","series-title":"Dengue: Clinical Diagnostics and Management [in Portuguese]","author":"Brazil","year":"2005"},{"key":"R27","series-title":"Clin Infect Dis","first-page":"1241","article-title":"Dengue-related deaths in Puerto Rico, 1992\u20131996: diagnosis and clinical alarm signals","volume":"42","author":"Rigau-P\u00e9rez","year":"2006"},{"key":"R28","series-title":"Singapore Med J","first-page":"476","article-title":"Do young adults with uncomplicated dengue fever need hospitalization? 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