{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:09:55Z","timestamp":1792638595963,"version":"4.5.0"},"reference-count":40,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,6]]},"abstract":"<jats:p>We investigated the effectiveness of routine preventive measures for anemia in Beninese pregnant women during pregnancy. Anemia (hemoglobin &lt; 110 g\/L) was common: 68.3% at first antenatal visit (ANV1), 64.7% at second antenatal visit (ANV2), and 40.6% at delivery. Parasitic infections and nutritional deficiencies were the most preventable causes. After intermittent preventive treatment (IPTp) and antihelminthic treatments, malaria prevalence decreased from 15.1% (ANV1) to 4.0% (ANV2) and increased again to 9.6% at delivery. Helminth infections dropped from 11.1% (ANV1) to 7.2% (ANV2) and 2.4% at delivery. Malaria was associated with lower mean hemoglobin on ANV1 and delivery, and iron deficiency was associated with lower mean hemoglobin on ANV1 and ANV2. IPTp and antihelminthic treatments were efficacious to clear parasitic infections and improve hematologic status, whereas the effectiveness of daily iron and folic acid supplements to correct iron and folate deficiencies and decrease anemia was less marked, possibly because of lack of compliance.<\/jats:p>","DOI":"10.4269\/ajtmh.12-0195","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T11:51:36Z","timestamp":1357645896000},"page":"292-300","source":"Crossref","is-referenced-by-count":51,"title":["Maternal Anemia in Pregnancy: Assessing the Effect of Routine Preventive Measures in a Malaria-Endemic Area"],"prefix":"10.4269","volume":"88","author":[{"given":"Sma\u00efla","family":"Ou\u00e9draogo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislain K.","family":"Koura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Bodeau-Livinec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred M. K.","family":"Accrombessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achille","family":"Massougbodji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Cot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Iron Deficiency Anaemia Assessment, Prevention, and Control. A Guide for Programme Managers","author":"WHO","year":"2001"},{"key":"R2","series-title":"Public Health Nutr","first-page":"444","article-title":"Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993\u20132005","volume":"12","author":"McLean","year":"2009"},{"key":"R3","series-title":"Food Nutr Bull","first-page":"S99","article-title":"Iron deficiency: global prevalence and consequences","volume":"24","author":"Stoltzfus","year":"2003"},{"key":"R4","series-title":"Am J Trop Med Hyg","first-page":"414","article-title":"Maternal anemia in Benin: prevalence, risk factors, and association with low birth weight","volume":"85","author":"Bodeau-Livinec","year":"2011"},{"key":"R5","series-title":"Br J Obstet Gynaecol","first-page":"385","article-title":"Anaemia in pregnancy in developing countries","volume":"105","author":"van den Broek","year":"1998"},{"key":"R6","series-title":"Am J Trop Med Hyg","first-page":"44","article-title":"An update on anemia in less developed countries","volume":"77","author":"Tolentino","year":"2007"},{"key":"R7","series-title":"Lancet","first-page":"2123","article-title":"Anaemia in low-income and middle-income countries","volume":"378","author":"Balarajan","year":"2011"},{"key":"R8","series-title":"Am J Trop Med Hyg","first-page":"418","article-title":"Maternal anaemia at first antenatal visit: prevalence and risk factors in a malaria endemic area in Benin","volume":"87","author":"Ou\u00e9draogo","year":"2012"},{"key":"R9","series-title":"JAMA","first-page":"2611","article-title":"Maternal hemoglobin concentration during pregnancy and risk of stillbirth","volume":"284","author":"Stephansson","year":"2000"},{"key":"R10","series-title":"Int J Gynaecol Obstet","first-page":"159","article-title":"Anemia during pregnancy in a Chinese population","volume":"83","author":"Xiong","year":"2003"},{"key":"R11","series-title":"Preventing and Controlling Iron Deficiency Through Primary Care","author":"De Maeyer","year":"1989"},{"key":"R12","series-title":"WHO Expert Committee on Malaria. Twentieth Report","author":"WHO","year":"2000"},{"key":"R13","series-title":"Weekly Iron-Folic Acid Supplementations (WIFS) in Women of Reproductive Age: Its Role in Promoting Optimal Maternal and Child Health Position Statement","author":"WHO","year":"2009"},{"key":"R14","series-title":"Clin Infect Dis","first-page":"531","article-title":"Effects of deworming during pregnancy on maternal and perinatal outcomes in Entebbe, Uganda: a randomized controlled trial","volume":"50","author":"Ndibazza","year":"2010"},{"key":"R15","series-title":"J Infect Dis","first-page":"163","article-title":"Decreased susceptibility to Plasmodium falciparum infection in pregnant women with iron deficiency","volume":"198","author":"Kabyemela","year":"2008"},{"key":"R16","series-title":"Am J Clin Nutr","first-page":"265S","article-title":"Iron needs during pregnancy: do we need to rethink our targets?","volume":"72","author":"Beaton","year":"2000"},{"key":"R17","series-title":"Ann Hematol","first-page":"959","article-title":"Prepartum anaemia: prevention and treatment","volume":"949","author":"Milman","year":"2008"},{"key":"R18","series-title":"Am J Obstet Gynecol","first-page":"440","article-title":"Plasma and red cell volumes during pregnancy","volume":"112","author":"Chesley","year":"1972"},{"key":"R19","series-title":"Clin Haematol","first-page":"601","article-title":"Blood volume changes in normal pregnancy","volume":"14","author":"Hytten","year":"1985"},{"key":"R20","series-title":"Parasitol Today","first-page":"469","article-title":"Malaria-related anaemia","volume":"16","author":"Menendez","year":"2000"},{"key":"R21","series-title":"Trop Med Int Health","first-page":"776","article-title":"Impact of hookworm infection and deworming on anaemia in non-pregnant populations: a systematic review","volume":"15","author":"Jennifer","year":"2010"},{"key":"R22","series-title":"Guidelines for the Use of Iron Supplements to Prevent and Treat Iron Deficiency Anemia","author":"Stoltzfus","year":"1998"},{"key":"R23","series-title":"PLoS One","first-page":"e1934","article-title":"A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic","volume":"3","author":"Menendez","year":"2008"},{"key":"R24","series-title":"J Infect Dis","first-page":"109","article-title":"Comparison of intermittent preventive treatment with chemoprophylaxis for the prevention of malaria during pregnancy in Mali","volume":"191","author":"Kayentao","year":"2005"},{"key":"R25","series-title":"Am J Trop Med Hyg","first-page":"1019","article-title":"A comparison of sulfadoxine-pyrimethamine with chloroquine and pyrimethamine for prevention of malaria in pregnant Nigerian women","volume":"76","author":"Tukur","year":"2007"},{"key":"R26","series-title":"JAMA","first-page":"2603","article-title":"Effect of sulfadoxine-pyrimethamine resistance on the efficacy of intermittent preventive therapy for malaria control during pregnancy: a systematic review","volume":"297","author":"ter Kuile","year":"2007"},{"key":"R27","series-title":"Am J Trop Med Hyg","first-page":"214","article-title":"Influence of the timing of malaria infection during pregnancy on birth weight and on maternal anemia in Benin","volume":"85","author":"Huynh","year":"2011"},{"key":"R28","series-title":"J Infect Dis","first-page":"57","article-title":"Comparison of sulfadoxine-pyrimethamine, unsupervised artemether-lumefantrine, and unsupervised artesunate-amodiaquine fixed-dose formulation for uncomplicated Plasmodium falciparum malaria in Benin: a randomized effectiveness noninferiority trial","volume":"200","author":"Faucher","year":"2009"},{"key":"R29","series-title":"Malar J","first-page":"196","article-title":"Molecular markers of resistance to sulphadoxine-pyrimethamine during intermittent preventive treatment of pregnant women in Benin","volume":"10","author":"Bertin","year":"2011"},{"key":"R30","series-title":"Preventing and Controlling Iron Deficiency Anaemia Through Primary Health Care. 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