{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T02:50:05Z","timestamp":1781837405692,"version":"3.54.5"},"reference-count":23,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,6]]},"abstract":"<jats:p>An uncommon disseminated <jats:italic>Mycobacterium tuberculosis<\/jats:italic> infection is described in a 12-year-old female dog presenting with fever, dyspnea, cough, weight loss, lymphadenopathy, melena, epistaxis, and emesis. The dog had a history of close contact with its owner, who died of pulmonary tuberculosis. Radiographic examination revealed diffuse radio-opaque images in both lung lobes, diffuse visible masses in abdominal organs, and hilar and mesenteric lymphadenopathy. Bronchial washing samples and feces were negative for acid-fast organisms. Polymerase chain reaction (PCR)-based species identification of bronchial washing samples, feces, and urine revealed <jats:italic>M. tuberculosis<\/jats:italic> using PCR-restriction enzyme pattern analysis-PRA. Because of public health concerns, which were worsened by the physical condition of the dog, euthanasia of the animal was recommended. Rough and tough colonies suggestive of <jats:italic>M. tuberculosis<\/jats:italic> were observed after microbiological culture of lung, liver, spleen, heart, and lymph node fragments in L\u00f6wenstein-Jensen and Stonebrink media. The PRA analysis enabled diagnosis of <jats:italic>M. tuberculosis<\/jats:italic> strains isolated from organs.<\/jats:p>","DOI":"10.4269\/ajtmh.12-0332","type":"journal-article","created":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T02:47:29Z","timestamp":1358822849000},"page":"596-600","source":"Crossref","is-referenced-by-count":29,"title":["Disseminated Mycobacterium tuberculosis Infection in a Dog"],"prefix":"10.4269","volume":"88","author":[{"given":"Anna Paula Vitirito","family":"Martinho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia Masello Junqueira","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio Garcia","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Belletti Mutt","family":"Perrotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Henriques","family":"Mangia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Megid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos","family":"Vulcano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Henrique Batista","family":"Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo Carlos Barreto","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarice Queico Fujimura","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osimar","family":"de Carvalho Sanches","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Carlos","family":"Paes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Manual de Recomenda\u00e7\u00f5es para o Controle da Tuberculose no Brasil","article-title":"Programa Nacional de Controle da Tuberculose. Secretaria de Vigil\u00e2ncia em Sa\u00fade","author":"Minist\u00e9rio da Sa\u00fade","year":"2011"},{"key":"R2","series-title":"Clinical Veterinary Microbiology","first-page":"137","author":"Quinn","year":"1994"},{"key":"R3","series-title":"J Clin Microbiol","first-page":"175","article-title":"Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis","volume":"31","author":"Telenti","year":"1993"},{"key":"R4","series-title":"Methods in Molecular Biology","first-page":"101","article-title":"Mycobacterium protocols","author":"Parish","year":"1998"},{"key":"R5","series-title":"Zoonosis y Enfermidades Transmisibles Communes al Hombre y a los Animals","first-page":"266","article-title":"Tuberculose zoon\u00f3tica","volume":"Volume I","author":"Acha","year":"2003"},{"key":"R6","series-title":"Infectious Diseases of the Dog and Cat","first-page":"334","article-title":"Mycobacterial infections","author":"Greene","year":"2012"},{"key":"R7","series-title":"J S Afr Vet Assoc","first-page":"95","article-title":"Pulmonary Mycobacterium tuberculosis (Beijing strain) infection in a stray dog","volume":"79","author":"Parsons","year":"2008"},{"key":"R8","series-title":"Manual de Bacteriologia da Tuberculose","article-title":"Centro de Refer\u00eancia Professor H\u00e9lio Fraga","author":"Minist\u00e9rio da Sa\u00fade","year":"2005"},{"key":"R9","series-title":"Identification of Mycobacteria","author":"Prasite","year":"2007"},{"key":"R10","series-title":"Mem Inst Oswaldo Cruz","first-page":"745","article-title":"Mycobacterium tuberculosis complex differentiation using gyrB restriction fragment length polymorphism analysis","volume":"99","author":"Chimara","year":"2004"},{"key":"R11","series-title":"Int J Tuberc Lung Dis","first-page":"1075","article-title":"Tuberculosis in humans and animals: an overview","volume":"14","author":"LoBue","year":"2010"},{"key":"R12","series-title":"Global Tuberculosis Control 2011","author":"World Health Organization-WHO","year":"2011"},{"key":"R13","series-title":"Res Vet Sci","first-page":"414","article-title":"Detection of Mycobacterium tuberculosis infection in dogs in a high-risk setting","volume":"92","author":"Parsons","year":"2011"},{"key":"R14","series-title":"Rev Saude Publica","first-page":"309","article-title":"Tuberculose canina e sua import\u00e2ncia em sa\u00fade p\u00fablica","volume":"28","author":"Megid","year":"1994"},{"key":"R15","series-title":"Arq Bras Med Vet Zootec","first-page":"410","article-title":"Isolamento de Mycobacterium bovis de c\u00e3o","volume":"53","author":"Mota","year":"2001"},{"key":"R16","series-title":"Aust Vet J","first-page":"320","article-title":"Disseminated Mycobacterium avium infection in a dog with chronic diarrhea","volume":"78","author":"Horn","year":"2000"},{"key":"R17","series-title":"J Vet Med B","first-page":"165","article-title":"PCR for detection of Mycobacterium tuberculosis in experimentally infected dogs","volume":"52","author":"Bonovska","year":"2005"},{"key":"R18","series-title":"Vet Clin Pathol","first-page":"177","article-title":"Mycobacterium tuberculosis infection in a dog from Africa","volume":"33","author":"Turinelli","year":"2004"},{"key":"R19","series-title":"J Vet Sci","first-page":"12","article-title":"Investigation of tuberculosis in army and police dogs in South China","volume":"28","author":"Ma","year":"1998"},{"key":"R20","series-title":"Vet Microbiol","first-page":"374","article-title":"Accidental infection of veterinary personnel with Mycobacterium tuberculosis at necropsy: a case study","volume":"149","author":"Posthaus","year":"2011"},{"key":"R21","series-title":"J Clin Microbiol","first-page":"3248","article-title":"High genetic diversity revealed by variable-number tandem repeat genotyping and analysis of hsp65 gene polymorphism in a large collection of Mycobacterium canetti strains indicates that the M. tuberculosis complex is a recently emerged clone of M. canetti","volume":"42","author":"Fabre","year":"2004"},{"key":"R22","series-title":"PLoS Negl Trop Dis","first-page":"e744","article-title":"Mycobacterium africanum\u2014review of an important cause of human tuberculosis in West Africa","volume":"4","author":"De Jong","year":"2010"},{"key":"R23","series-title":"Emerg Infect Dis","first-page":"2258","article-title":"Mycobacterium tuberculosis transmission from human to canine","volume":"12","author":"Erwin","year":"2004"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/88\/3\/article-p596.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/88\/3\/article-p596.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/88\/3\/article-p596.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:40:32Z","timestamp":1723056032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/88\/3\/article-p596.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,6]]},"references-count":23,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.12-0332","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,6]]}}}