{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:50:45Z","timestamp":1789977045366,"version":"4.0.1"},"reference-count":30,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,5]]},"abstract":"<jats:p>Parasitic infections are associated with high morbidity and mortality in developing countries. Several studies focused on the influence of helminth infections on malaria but the nature of the biological interaction is under debate. Our objective was to undertake a study to explore the influence of the measure of excreted egg load caused by <jats:italic>Schistosoma haematobium<\/jats:italic> on <jats:italic>Plasmodium falciparum<\/jats:italic> parasite densities. Ten measures of malaria parasite density and two measures of schistosomiasis egg urinary excretion over a 2-year follow-up period on 178 Senegalese children were considered. A linear mixed-effect model was developed to take data dependence into account. This work showed that children with a light <jats:italic>S. haematobium<\/jats:italic> infection (1\u20139 eggs\/mL of urine) presented lower <jats:italic>P. falciparum<\/jats:italic> parasite densities than children not infected by <jats:italic>S. haematobium<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt; 0.04). Possible changes caused by parasite coinfections should be considered in the anti-helminth treatment of children and in malaria vaccination development.<\/jats:p>","DOI":"10.4269\/ajtmh.12-0431","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T04:51:24Z","timestamp":1386651084000},"page":"329-334","source":"Crossref","is-referenced-by-count":46,"title":["Coinfection with Plasmodium falciparum and Schistosoma haematobium: Additional Evidence of the Protective Effect of Schistosomiasis on Malaria in Senegalese Children"],"prefix":"10.4269","volume":"90","author":[{"given":"Magali","family":"Lemaitre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Watier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Briand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Yves","family":"Le Hesran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Cot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Parasitol Res","first-page":"544","article-title":"Heterologous synergistic interactions in concurrent experimental infection in the mouse with Schistosoma mansoni, Echinostoma revolutum, Plasmodium yoelii, Babesia microti, and Trypanosoma brucei","volume":"74","author":"Christensen","year":"1988"},{"key":"R2","series-title":"Int Immunol","first-page":"1117","article-title":"Schistosoma mansoni infection cancels the susceptibility to Plasmodium chabaudi through induction of type 1 immune responses in A\/J mice","volume":"12","author":"Yoshida","year":"2000"},{"key":"R3","series-title":"Parasite Immunol","first-page":"207","article-title":"Anti-schistosome antibody responses in children coinfected with malaria","volume":"22","author":"Mutapi","year":"2000"},{"key":"R4","series-title":"Int J Parasitol","first-page":"1041","article-title":"The effect of helminth co-infection on malaria in mice: a meta-analysis","volume":"41","author":"Knowles","year":"2011"},{"issue":"(Suppl)","key":"R5","series-title":"Parasitology","first-page":"S23","article-title":"Concomitant infections, parasites and immune responses","volume":"122","author":"Cox","year":"2001"},{"key":"R6","series-title":"Malar J","first-page":"259","article-title":"Interactions between worms and malaria: good worms or bad worms?","volume":"10","author":"Nacher","year":"2011"},{"key":"R7","series-title":"Am J Trop Med Hyg","first-page":"702","article-title":"Coinfection with Plasmodium falciparum and Schistosoma haematobium: protective effect of schistosomiasis on malaria in Senegalese children?","volume":"72","author":"Briand","year":"2005"},{"key":"R8","series-title":"Am J Trop Med Hyg","first-page":"1124","article-title":"Association of Schistosoma haematobium infection with protection against acute Plasmodium falciparum malaria in Malian children","volume":"73","author":"Lyke","year":"2005"},{"key":"R9","series-title":"Infect Immun","first-page":"5718","article-title":"Effects of concomitant Schistosoma haematobium infection on the serum cytokine levels elicited by acute Plasmodium falciparum malaria infection 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Background and methodology of a longitudinal study of clinical, parasitological and immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study)","volume":"10","author":"Wiria","year":"2010"},{"key":"R20","series-title":"PLoS ONE","first-page":"e9309","article-title":"Understanding human-Plasmodium falciparum immune interactions uncovers the immunological role of worms","volume":"5","author":"Roussilhon","year":"2010"},{"key":"R21","series-title":"PLoS Negl Trop Dis","first-page":"e887","article-title":"Complex interactions between soil-transmitted helminths and malaria in pregnant women on the Thai-Burmese border","volume":"4","author":"Boel","year":"2010"},{"key":"R22","series-title":"Parasite Immunol","first-page":"365","article-title":"Schistosomiasis co-infection in humans influences inflammatory markers in uncomplicated Plasmodium falciparum malaria","volume":"26","author":"Diallo","year":"2004"},{"key":"R23","series-title":"BMC Infect Dis","first-page":"158","article-title":"Effect of treating Schistosoma haematobium infection on Plasmodium falciparum-specific antibody responses","volume":"8","author":"Reilly","year":"2008"},{"key":"R24","series-title":"Am J Trop Med Hyg","first-page":"1091","article-title":"Confirmation of the protective effect of Ascaris lumbricoides on Plasmodium falciparum infection: results of a randomized trial in Madagascar","volume":"77","author":"Brutus","year":"2007"},{"key":"R25","series-title":"Am J Trop Med Hyg","first-page":"194","article-title":"Parasitic co-infections: does Ascaris lumbricoides protect against Plasmodium falciparum infection?","volume":"75","author":"Brutus","year":"2006"},{"key":"R26","series-title":"BMC Infect Dis","first-page":"277","article-title":"Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial","volume":"10","author":"Kirwan","year":"2010"},{"key":"R27","series-title":"Infect Immun","first-page":"3347","article-title":"Identification of a novel antigen of Schistosoma mansoni shared with Plasmodium falciparum and evaluation of different cross-reactive antibody subclasses induced by human schistosomiasis and malaria","volume":"74","author":"Pierrot","year":"2006"},{"key":"R28","series-title":"J Infect Dis","first-page":"1272","article-title":"Serological responses among individuals in areas where both schistosomiasis and malaria are endemic: cross-reactivity between Schistosoma mansoni and Plasmodium falciparum","volume":"187","author":"Naus","year":"2003"},{"key":"R29","series-title":"Trans R Soc Trop Med Hyg","first-page":"361","article-title":"Malaria co-infection in children influences antibody response to schistosome antigens and inflammatory markers associated with morbidity","volume":"97","author":"Remoue","year":"2003"},{"key":"R30","series-title":"Afr J Med Med Sci","first-page":"9","article-title":"Complement factors and circulating immune complexes in children with urinary schistosomiasis and asymptomatic malaria","volume":"34","author":"Arinola","year":"2005"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/90\/2\/article-p329.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/90\/2\/article-p329.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/90\/2\/article-p329.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:33:25Z","timestamp":1723066405000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/90\/2\/article-p329.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,5]]},"references-count":30,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.12-0431","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,5]]}}}