{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T18:38:04Z","timestamp":1771353484765,"version":"3.50.1"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,5]]},"abstract":"<jats:p>Hemophagocytic syndrome is a rare disease that is often fatal, despite treatment. An immunocompetent patient was presented with fever, hepatosplenomegaly, cytopenias, hypertriglyceridemia, hypofibrinogenemia, and hyperferritinemia, which conformed to a hemophagocytic syndrome diagnosis. Despite broad antibiotic treatment, the patient's clinical condition rapidly deteriorated and he died within 8 days of admission. Blood cultures and a serology test were negative; however, based on morphological characteristics, tissue cysts <jats:italic>Toxoplasma gondii<\/jats:italic> were found in the bone marrow. Based on polymerase chain reaction analysis, identity of the parasite was confirmed. Although very rare, <jats:italic>T. gondii<\/jats:italic>-associated hemophagocytic syndrome should be suspected in the case of cytopenia or multiorgan failure symptoms. To our knowledge, this is the first fatal toxoplasmosis case reported from China.<\/jats:p>","DOI":"10.4269\/ajtmh.12-0556","type":"journal-article","created":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T07:15:38Z","timestamp":1363677338000},"page":"1209-1211","source":"Crossref","is-referenced-by-count":8,"title":["Hemophagocytic Syndrome as Uncommon Presentation of Disseminated Toxoplasmosis in an Immunocompetent Adult from Chinese Kunming"],"prefix":"10.4269","volume":"88","author":[{"given":"YanFen","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WeiWei","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JunJie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald W.","family":"Esch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YangXian","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Lancet","first-page":"579","article-title":"Severe acute disseminated toxoplasmosis","volume":"364","author":"Bossi","year":"2004"},{"key":"R2","series-title":"Lancet Infect Dis","first-page":"814","article-title":"Infections associated with hemophagocytic syndrome","volume":"7","author":"Rouphael","year":"2007"},{"key":"R3","series-title":"Eur J Intern Med","first-page":"503","article-title":"Hemophagocytic syndrome associated with extracerebral toxoplasmosis in an HIV-infected patient","volume":"17","author":"Guillaume","year":"2006"},{"key":"R4","series-title":"Clin Infect Dis","first-page":"989","article-title":"Toxoplasmosis-associated hemophagocytic syndrome in a patient with AIDS: diagnosis by the polymerase chain reaction","volume":"19","author":"Blanche","year":"1994"},{"key":"R5","series-title":"Transplantation","first-page":"238","article-title":"Hemophagocytic syndrome in renal transplant recipients: report of 17 cases and review of literature","volume":"77","author":"Karras","year":"2004"},{"key":"R6","series-title":"Transpl Infect Dis","first-page":"372","article-title":"Toxoplasmosis with hemophagocytic syndrome after bone marrow transplantation: diagnosis at autopsy","volume":"10","author":"Duband","year":"2008"},{"key":"R7","series-title":"Int J Parasitol","first-page":"69","article-title":"Identification of a 200- to 300-fold repetitive 529 bp DNA fragment in Toxoplasma gondii, and its use for diagnostic and quantitative PCR","volume":"30","author":"Homan","year":"2000"},{"key":"R8","series-title":"BMC Infect Dis","first-page":"4","article-title":"Seroepidemiology of human Toxoplasma gondii infection in China","volume":"10","author":"Xiao","year":"2001"},{"key":"R9","series-title":"Lancet","first-page":"1965","article-title":"Toxoplasmosis","volume":"363","author":"Montoya","year":"2004"},{"key":"R10","series-title":"Neurol Sci","first-page":"45","article-title":"Unusual cause of dementia in an immunocompetent host: toxoplasmic encephalitis","volume":"30","author":"Habek","year":"2009"},{"key":"R11","series-title":"Infez Med","first-page":"48","article-title":"Acute pericarditis and myocarditis by Toxoplasma gondii in an immunocompetent young man: a case report","volume":"18","author":"Pergola","year":"2010"},{"key":"R12","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"107","article-title":"Disseminated toxoplasmosis in an immunocompetent patient from Peruvian Amazon","volume":"52","author":"Nunura","year":"2010"},{"key":"R13","series-title":"Semin Oncol","first-page":"29","article-title":"Diagnostic guidelines for hemophagocytic lymphohistiocytosis. The FHL Study Group of the Histiocyte Society","volume":"18","author":"Henter","year":"1991"},{"key":"R14","series-title":"Pediatr Blood Cancer","first-page":"124","article-title":"HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter","year":"2007"},{"key":"R15","series-title":"Ann Biol Clin (Paris)","first-page":"199","article-title":"Hemophagocytic syndrome and toxoplasmic primo-infection","volume":"66","author":"Briand","year":"2008"},{"key":"R16","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"113","article-title":"Disseminated toxoplasmosis presenting as sepsis in two AIDS patients","volume":"49","author":"Barbosa","year":"2007"},{"key":"R17","series-title":"Chest","first-page":"1054","article-title":"Septic shock due to toxoplasmosis in patients infected with the human immunodeficiency virus","volume":"104","author":"Lucet","year":"1993"},{"key":"R18","series-title":"Parasitology","first-page":"1","article-title":"Moving towards an integrated approach to molecular detection and identification of Toxoplasma gondii","volume":"137","author":"Su","year":"2010"},{"key":"R19","series-title":"Int J Parasitol","first-page":"1257","article-title":"Toxoplasma gondii infection in humans and animals in the United States","volume":"38","author":"Dubey","year":"2008"},{"key":"R20","series-title":"Int J Parasitol","first-page":"1217","article-title":"Toxoplasma gondii: from animals to humans","volume":"30","author":"Tenter","year":"2000"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/88\/6\/article-p1209.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/88\/6\/article-p1209.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/88\/6\/article-p1209.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:30:47Z","timestamp":1723055447000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/88\/6\/article-p1209.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,5]]},"references-count":20,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.12-0556","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,5]]}}}