{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:10:21Z","timestamp":1773238221706,"version":"3.50.1"},"reference-count":29,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,6]]},"abstract":"<jats:p>Rocio virus (ROCV) caused an outbreak of human encephalitis during the 1970s in Brazil and its immunopathogenesis remains poorly understood. CC-chemokine receptor 5 (CCR5) is a chemokine receptor that binds to macrophage inflammatory protein (MIP-1 \u03b1). Both molecules are associated with inflammatory cells migration during infections. In this study, we demonstrated the importance of the CCR5 and MIP-1 \u03b1, in the outcome of viral encephalitis of ROCV-infected mice. CCR5 and MIP-1 \u03b1 knockout mice survived longer than wild-type (WT) ROCV-infected animals. In addition, knockout mice had reduced inflammation in the brain. Assessment of brain viral load showed mice virus detection five days post-infection in wild-type and CCR5\u2212\/\u2212 mice, while MIP-1 \u03b1\u2212\/\u2212 mice had lower viral loads seven days post-infection. Knockout mice required a higher lethal dose than wild-type mice as well. The CCR5\/MIP-1 \u03b1 axis may contribute to migration of infected cells to the brain and consequently affect the pathogenesis during ROCV infection.<\/jats:p>","DOI":"10.4269\/ajtmh.12-0591","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T06:03:30Z","timestamp":1380607410000},"page":"1013-1018","source":"Crossref","is-referenced-by-count":15,"title":["Influence of the CCR-5\/MIP-1 \u03b1 Axis in the Pathogenesis of Rocio Virus Encephalitis in a Mouse Model"],"prefix":"10.4269","volume":"89","author":[{"given":"Juliana H.","family":"Ch\u00e1vez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael F. O.","family":"Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo J. F.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T. P.","family":"de Aquino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kleber J. S.","family":"Farias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula R. L.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thelma F. M.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonny","family":"Yokosawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson G.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o S.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedito A. 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