{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:16:49Z","timestamp":1787624209436,"version":"build-2736575974"},"reference-count":70,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,5]]},"abstract":"<jats:p>Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in Africa and rapidly spread into countries of the Indian Ocean basin and South-East Asia. The mean viremic blood donation risk for CHIKV on La R\u00e9union reached 1.5% at the height of the 2005\u20132006 outbreaks, highlighting the need for development of safety measures to prevent transfusion-transmitted infections. We describe successful inactivation of CHIKV in human platelets and plasma using photochemical treatment with amotosalen and long wavelength UVA illumination. Platelet components in additive solution and plasma units were inoculated with two different strains of high titer CHIKV stock (6.0\u20138.0 logs\/mL), and then treated with amotosalen and exposure to 1.0\u20133.0 J\/cm<jats:sup>2<\/jats:sup> UVA. Based on <jats:italic>in vitro<\/jats:italic> assays of infectious virus pre- and post-treatment to identify endpoint dilutions where virus was not detectable, mean viral titers could effectively be reduced by &gt; 6.4 \u00b1 0.6 log<jats:sub>10<\/jats:sub> TCID<jats:sub>50<\/jats:sub>\/mL in platelets and \u2265 7.6 \u00b1 1.4 logs in plasma, indicating this treatment has the capacity to prevent CHIKV transmission in human blood components collected from infected donors in or traveling from areas of CHIKV transmission.<\/jats:p>","DOI":"10.4269\/ajtmh.12-0603","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T01:38:40Z","timestamp":1364261920000},"page":"1163-1169","source":"Crossref","is-referenced-by-count":24,"title":["Photochemical Inactivation of Chikungunya Virus in Human Apheresis Platelet Components by Amotosalen and UVA Light"],"prefix":"10.4269","volume":"88","author":[{"given":"Konstantin A.","family":"Tsetsarkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Sampson-Johannes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Sawyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kinsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Higgs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana L.","family":"Vanlandingham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Transfus Med Rev","first-page":"15","article-title":"Chikungunya virus: possible impact on transfusion 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