{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T06:03:38Z","timestamp":1785564218880,"version":"3.56.0"},"reference-count":73,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,4]]},"abstract":"<jats:p>Children (n = 812) 6\u201311 years of age attending 16 schools in the Kintampo North Municipality of Ghana were screened for participation in a study on hookworm infection, nutrition, and response to albendazole. The prevalence of <jats:italic>Necator americanus<\/jats:italic> hookworm infection (n = 286) was 39.1%, and significant predictors of infection included age, malaria parasitemia, lack of health care, school area, levels of antibodies against hookworm, and low consumption of animal foods. The cure rate after a single dose (400 mg) albendazole was 43%, and the mean fecal egg count reduction rate was 87.3%. Data for an <jats:italic>in vitro<\/jats:italic> egg hatch assay showed a trend toward reduced albendazole susceptibility in post-treatment hookworm isolates (<jats:italic>P<\/jats:italic> = 0.06). In summary, hookworm infection is prevalent among school age children in the Kintampo North Municipality and animal food intake inversely correlates with infection status. Modest cure rates and fecal egg count reduction rates reinforce the need for further investigation of potential benzimidazole resistance in Ghana.<\/jats:p>","DOI":"10.4269\/ajtmh.12-0605","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T01:59:27Z","timestamp":1373335167000},"page":"540-548","source":"Crossref","is-referenced-by-count":55,"title":["Hookworm Infection among School Age Children in Kintampo North Municipality, Ghana: Nutritional Risk Factors and Response to Albendazole Treatment"],"prefix":"10.4269","volume":"89","author":[{"given":"Debbie","family":"Humphries","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin T.","family":"Simms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Davey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Otchere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Quagraine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Terryah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyssa","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Boakye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Cappello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Curr Infect Dis Rep","first-page":"210","article-title":"Twenty-first century progress toward the global control of human hookworm infection","volume":"13","author":"Bungiro","year":"2011"},{"key":"R2","series-title":"Trends Parasitol","first-page":"547","article-title":"Soil-transmitted helminth infections: updating the global picture","volume":"19","author":"de Silva","year":"2003"},{"key":"R3","series-title":"Lancet","first-page":"1521","article-title":"Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm","volume":"367","author":"Bethony","year":"2006"},{"key":"R4","series-title":"J Nutr","first-page":"1036","article-title":"Physical fitness, growth and appetite of Kenyan school boys with hookworm, Trichuris trichiura and Ascaris lumbricoides infections are improved four months after a single dose of albendazole","volume":"123","author":"Stephenson","year":"1993"},{"key":"R5","series-title":"Trans R Soc Trop Med Hyg","first-page":"277","article-title":"Improvements in physical fitness of Kenyan schoolboys infected with hookworm, Trichuris trichiura and Ascaris lumbricoides following a single dose of albendazole","volume":"84","author":"Stephenson","year":"1990"},{"key":"R6","series-title":"Am J Trop Med Hyg","first-page":"78","article-title":"Treatment with a single dose of albendazole improves growth of Kenyan schoolchildren with hookworm, Trichuris trichiura, and Ascaris lumbricoides infections","volume":"41","author":"Stephenson","year":"1989"},{"key":"R7","series-title":"Ann N Y Acad Sci","first-page":"38","article-title":"Hookworm and poverty","volume":"1136","author":"Hotez","year":"2008"},{"key":"R8","series-title":"Am J Trop Med Hyg","first-page":"36","article-title":"The effect of the availability of latrines on soil-transmitted nematode infections in the plantation sector in Sri Lanka","volume":"51","author":"Sorensen","year":"1994"},{"key":"R9","series-title":"Southeast Asian J Trop Med Public Health","first-page":"998","article-title":"An unceasing problem: soil-transmitted helminthiases in rural Malaysian communities","volume":"38","author":"Al-Mekhlafi","year":"2007"},{"key":"R10","series-title":"Factors Associated with Anemia: Anti-erythrocyte Antibodies in Mice with Schistosoma mansoni; 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