{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:09:01Z","timestamp":1791065341096,"version":"4.1.0"},"reference-count":34,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,6]]},"abstract":"<jats:p>\n                    We evaluated a commercial point-of-care circulating cathodic antigen (POC-CCA) test for assessing\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    infection prevalence in areas at risk. Overall, 4,405 school-age children in Cameroon, C\u00f4te d'Ivoire, Ethiopia, Kenya, and Uganda provided urine for POC-CCA testing and stool for Kato-Katz assays. By latent class analysis, one POC-CCA test was more sensitive (86% versus 62%) but less specific (72% versus \u223c100%) than multiple Kato-Katz smears from one stool. However, only 1% of POC-CCA tests in a non-endemic area were false positives, suggesting the latent class analysis underestimated the POC-CCA specificity. Multivariable modeling estimated POC-CCA as significantly more sensitive than Kato-Katz at low infection intensities (&lt; 100 eggs\/gram stool). By linear regression, 72% prevalence among 9\u201312 year olds by POC-CCA corresponded to 50% prevalence by Kato-Katz, whereas 46% POC-CCA prevalence corresponded to 10% Kato-Katz prevalence. We conclude that one urine POC-CCA test can replace Kato-Katz testing for community-level\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    prevalence mapping.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.12-0639","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T21:47:29Z","timestamp":1358804849000},"page":"426-432","source":"Crossref","is-referenced-by-count":214,"title":["A Five-Country Evaluation of a Point-of-Care Circulating Cathodic Antigen Urine Assay for the Prevalence of Schistosoma mansoni"],"prefix":"10.4269","volume":"88","author":[{"given":"Daniel G.","family":"Colley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles H.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis-Albert","family":"Tchuem Tchuent\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli\u00e9zer K.","family":"N'Goran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berhanu","family":"Erko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana M. S.","family":"Karanja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narcis B.","family":"Kabatereine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette","family":"van Lieshout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Rathbun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"397","article-title":"A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni","volume":"14","author":"Katz","year":"1972"},{"key":"R2","series-title":"Preventive Chemotherapy in Human Helminthiasis: Coordinated Use of Anthelminthic Drugs in Control Interventions: A Manual For Health Professionals and Programme Managers","author":"WHO","year":"2006"},{"key":"R3","series-title":"First WHO Report on Neglected Tropical Diseases 2010: Working to Overcome the Global Impact of Neglected Tropical Diseases","author":"WHO","year":"2010"},{"key":"R4","series-title":"Parasitol Today","first-page":"274","article-title":"Underestimation of Schistosoma mansoni prevalences","volume":"8","author":"de Vlas","year":"1992"},{"key":"R5","series-title":"Parasitology","first-page":"537","article-title":"Relative contribution of day-to-day and intra-specimen variation in fecal egg counts of Schistosoma mansoni before and after treatment with praziquantel","volume":"122","author":"Utzinger","year":"2001"},{"key":"R6","series-title":"Trop Med Int Health","first-page":"402","article-title":"Response to: accuracy of circulating cathodic antigen tests for rapid mapping of Schistosoma mansoni and S. haematobium infections in southern Sudan by RA Ashton et al. (2011) Trop Med Int Health 16, pp. 1099\u20131103","volume":"17","author":"Deelder","year":"2012"},{"key":"R7","series-title":"Trop Med Int Health","first-page":"647","article-title":"Rapid assessment of Schistosoma mansoni: the validity, applicability and cost-effectiveness of the Lot Quality Assurance Sampling method in Uganda","volume":"10","author":"Brooker","year":"2005"},{"key":"R8","series-title":"Trends Parasitol","first-page":"151","article-title":"Diagnostic dilemmas in helminthology: what tools to use and when?","volume":"25","author":"Bergquist","year":"2009"},{"key":"R9","series-title":"Bull World Health Organ","first-page":"673","article-title":"Integration of mass drug administration programmes in Nigeria: the challenge of schistosomiasis","volume":"84","author":"Richards","year":"2006"},{"key":"R10","series-title":"PLoS Negl Trop Dis","first-page":"e1746","article-title":"A diagnostics platform for the integrated mapping, monitoring, and surveillance of neglected 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Parasitol","first-page":"625","article-title":"Application of a circulating-cathodic-antigen (CCA) strip test and real-time PCR, in comparison with microscopy, for the detection of Schistosoma haematobium in urine samples from Ghana","volume":"102","author":"Obeng","year":"2008"},{"key":"R19","series-title":"Parasitology","first-page":"113","article-title":"Validation of a chart to estimate true Schistosoma mansoni prevalences from simple egg counts","volume":"114","author":"de Vlas","year":"1997"},{"key":"R20","series-title":"Stat Med","first-page":"21","article-title":"The value of latent class analysis in medical diagnosis","volume":"5","author":"Rindskopf","year":"1986"},{"key":"R21","series-title":"Biometrics","first-page":"587","article-title":"Using latent class models to characterize and assess relative error in discrete measurements","volume":"45","author":"Espeland","year":"1989"},{"key":"R22","series-title":"Int J Parasitol","first-page":"759","article-title":"Reduction in 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