{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:57:42Z","timestamp":1762459062149},"reference-count":32,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:p>Chloroquine (CQ) is officially used for the primary treatment of <jats:italic>Plasmodium falciparum<\/jats:italic> malaria in Honduras. In this study, the therapeutic efficacy of CQ for the treatment of uncomplicated <jats:italic>P. falciparum<\/jats:italic> malaria in the municipality of Puerto Lempira, Gracias a Dios, Honduras was evaluated using the Pan American Health Organization\u2014World Health Organization protocol with a follow-up of 28 days. Sixty-eight patients from 6 months to 60 years of age microscopically diagnosed with uncomplicated <jats:italic>P. falciparum<\/jats:italic> malaria were included in the final analysis. All patients who were treated with CQ (25 mg\/kg over 3 days) cleared parasitemia by day 3 and acquired no new <jats:italic>P. falciparum<\/jats:italic> infection within 28 days of follow-up. All the parasite samples sequenced for CQ resistance mutations (<jats:italic>pfcrt<\/jats:italic>) showed only the CQ-sensitive genotype (CVMNK). This finding shows that CQ remains highly efficacious for the treatment of uncomplicated <jats:italic>P. falciparum<\/jats:italic> malaria in Gracias a Dios, Honduras.<\/jats:p>","DOI":"10.4269\/ajtmh.12-0671","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T11:32:46Z","timestamp":1362483166000},"page":"850-854","source":"Crossref","is-referenced-by-count":27,"title":["Efficacy of Chloroquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Honduras"],"prefix":"10.4269","volume":"88","author":[{"given":"Rosa Elena","family":"Mejia Torres","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Engels Ilich","family":"Banegas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meisy","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Tamara Mancero","family":"Bucheli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo A.","family":"Fontecha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Tauqeer","family":"Alam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatachalam","family":"Udhayakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Orlinder Nicolas","family":"Zambrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"BMJ","first-page":"95","article-title":"Malaria. 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