{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:47:56Z","timestamp":1791128876924,"version":"4.1.0"},"reference-count":16,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:p>Granada virus (GRV), a new phlebovirus within the Naples serocomplex, has been recently described in phlebotomine sandflies from Spain. The presence of anti-GRV immunoglobulin G (IgG) antibodies was investigated by indirect fluorescence assay (IFA) and neutralization test (NT) in 920 serum samples from the Granada population. By IFA, an overall GRV seroprevalence of 15.8% (<jats:italic>N<\/jats:italic> = 145) was observed, significantly increasing up to 65 years. NT was positive in 18% of anti-GRV IFA-positive samples. IgG antibodies against Toscana virus (TOSV), a hyperendemic phlebovirus within Granada province, were detected in 40% of anti-GRV\u2013positive cases. Anti-GRV IgM antibodies were detected in 36 (6.6%) of 547 acute-phase serum samples from individuals with febrile illness, exanthema, and\/or acute respiratory infection. All positives were anti-TOSV IgM-negative. GRV may infect humans, with most cases being asymptomatic. The codetection of anti-GRV and anti-TOSV IgG antibodies could be attributable to cross-reactivity or exposure to the same transmission vector.<\/jats:p>","DOI":"10.4269\/ajtmh.12-0732","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T13:28:45Z","timestamp":1361280525000},"page":"1003-1006","source":"Crossref","is-referenced-by-count":15,"title":["Clinic\u2013Epidemiologic Study of Human Infection by Granada Virus, a New Phlebovirus within the Sandfly Fever Naples Serocomplex"],"prefix":"10.4269","volume":"88","author":[{"given":"Jos\u00e9 Mar\u00eda","family":"Navarro-Mar\u00ed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"G\u00f3mez-Camarasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"P\u00e9rez-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sanbonmatsu-G\u00e1mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Pedrosa-Corral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Jim\u00e9nez-Valera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Med Clin (Barc)","first-page":"420","article-title":"Meningitis by Toscana virus in Spain: description of 17 cases","volume":"122","author":"Navarro","year":"2004"},{"key":"R2","series-title":"Emerg Infect Dis","first-page":"1701","article-title":"Toscana virus in Spain","volume":"11","author":"Sanbonmatsu-G\u00e1mez","year":"2005"},{"key":"R3","series-title":"Int J Neurosci","first-page":"165","article-title":"Personality changes after Toscana virus (TOSV) encephalitis in a 49-year-old man: a case report","volume":"121","author":"Serata","year":"2011"},{"key":"R4","series-title":"J Neurol","first-page":"175","article-title":"Lethal encephalitis caused by the Toscana virus in an elderly patient","volume":"259","author":"Bartels","year":"2012"},{"key":"R5","series-title":"Emerg Infect Dis","first-page":"347","article-title":"Unusual manifestation of Toscana virus infection, Spain","volume":"15","author":"Sanbonmatsu-G\u00e1mez","year":"2009"},{"key":"R6","series-title":"J Clin Virol","first-page":"104","article-title":"Acute Toscana virus infection mimicked by Yersinia-induced reactive 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Mediterranean","volume":"9","author":"Charrel","year":"2009"},{"key":"R11","series-title":"Diagnostic Methods in Clinical Virology","first-page":"81","article-title":"Neutralization tests","author":"Grist","year":"1979"},{"key":"R12","series-title":"Vector Borne Zoonotic Dis","first-page":"781","article-title":"Performance of various commercial assays for the detection of Toscana virus antibodies","volume":"11","author":"Erg\u00fcnay","year":"2011"},{"key":"R13","series-title":"PLoS Negl Trop Dis","first-page":"e1328","article-title":"Epidemiologic relationship between Toscana virus infection and Leishmania infantum due to common exposure to Phlebotomus perniciosus sandfly vector","volume":"5","author":"Bichaud","year":"2011"},{"key":"R14","series-title":"Enferm Infecc Microbiol Clin","first-page":"187","article-title":"Age-dependent seroprevalence of Toscana virus in the Community of Madrid: 1993\u20131994 and 1999\u20132000","volume":"25","author":"de Ory-Manch\u00f3n","year":"2007"},{"key":"R15","series-title":"Arch Virol Suppl","first-page":"41","article-title":"Sandfly fever viruses in Italy","volume":"11","author":"Nicoletti","year":"1996"},{"key":"R16","series-title":"J Med Virol","first-page":"140","article-title":"Detection and identification of Toscana and other phleboviruses by RT-nested-PCR assays with degenerated primers","volume":"71","author":"S\u00e1nchez-Seco","year":"2003"}],"container-title":["The American Society of Tropical Medicine and 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