{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:17:05Z","timestamp":1776921425390,"version":"3.51.2"},"reference-count":29,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,4]]},"abstract":"<jats:p>In this randomized, double-blinded Phase 2 trial, 30 patients with <jats:italic>Leishmania panamensis<\/jats:italic> cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% gentamicin) or Paromomycin Alone (15% paromomycin) for 20 days. The index lesion cure rate after 6 months follow-up was 13 of 15 (87%) for WR 279,396 and 9 of 15 (60%) for Paromomycin Alone (<jats:italic>P<\/jats:italic> = 0.099). When all treated lesions were included, the final cure rate for WR 279,398-treated patients was again 87%, but the final cure rate for Paromomycin Alone-treated patients was 8 of 15 (53.3%; <jats:italic>P<\/jats:italic> = 0.046). Both creams were well tolerated with mild application site reactions being the most frequent adverse event. The increased final cure rate in the WR 279,396 group in this small Phase 2 study suggests that the combination product may provide greater clinical benefit than paromomycin monotherapy against <jats:italic>L. panamensis<\/jats:italic> cutaneous leishmaniasis.<\/jats:p>","DOI":"10.4269\/ajtmh.12-0736","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T04:56:02Z","timestamp":1373950562000},"page":"557-563","source":"Crossref","is-referenced-by-count":46,"title":["Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in 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