{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T03:53:12Z","timestamp":1775879592675,"version":"3.50.1"},"reference-count":34,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,5]]},"abstract":"<jats:p>Our study investigated the possible impact of SP-IPT given to infants and children on the prevalence of SP-resistant haplotypes in the <jats:italic>Plasmodium falciparum<\/jats:italic> genes <jats:italic>Pfdhfr<\/jats:italic> and <jats:italic>Pfdhps<\/jats:italic>, comparing sites with and without IPTi\/c. <jats:italic>P. falciparum<\/jats:italic> positive samples (N = 352) collected from children &lt; 5 years were analyzed to determine the prevalence of SP resistance-related haplotypes by nested PCR followed by sequence-specific oligonucleotide probe-enzyme-linked immunosorbent assay. The prevalence of the <jats:italic>Pfdhfr<\/jats:italic> triple mutant haplotype (CIRN) increased in both groups, but only significantly in the IPTi\/c group from 41% to 65% in 2011 (<jats:italic>P<\/jats:italic> = 0.005). Conversely, the <jats:italic>Pfdhps<\/jats:italic> 437G mutation decreased in both groups from 44.6% to 28.6% (<jats:italic>P<\/jats:italic> = 0.07) and from 66.7% to 47.5% (<jats:italic>P<\/jats:italic> = 0.02) between 2010 and 2011 in the control and the IPTi\/c groups, respectively. A weak trend for decreasing prevalence of quadruple mutants (triple <jats:italic>Pfdhfr<\/jats:italic> + <jats:italic>Pfdhps<\/jats:italic> 437G) was noted in both groups (<jats:italic>P<\/jats:italic> = 0.15 and <jats:italic>P<\/jats:italic> = 0.34). During the two cross-sectional surveys some significant changes were observed in the SP resistance-related genes.<\/jats:p>","DOI":"10.4269\/ajtmh.12-0739","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T01:42:41Z","timestamp":1366076561000},"page":"1124-1129","source":"Crossref","is-referenced-by-count":6,"title":["Selection of Antimalarial Drug Resistance after Intermittent Preventive Treatment of Infants and Children (IPTi\/c) in Senegal"],"prefix":"10.4269","volume":"88","author":[{"given":"Magatte","family":"Ndiaye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Tine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babacar","family":"Faye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean 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