{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:51:23Z","timestamp":1765885883680},"reference-count":34,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,7]]},"abstract":"<jats:p>Treatment alternatives have seldom been evaluated in children with cutaneous leishmaniasis (CL). We examine the clinical\/epidemiological profile of children with CL considering international guidelines for local treatment. Descriptive analyses were conducted using International Center for Medical Research and Training (CIDEIM) case reports of parasitologically diagnosed patients \u2264 14 years of age from 2004 to 2010. Eligibility for local treatment based on World Health Organization\/Pan American Health Organization (WHO\/PAHO) criteria was determined. Among 380 children, 90% presented lesions of &lt; 3 months duration, 54% presented single lesions &lt; 30 mm in diameter, and 45% were \u2264 5 years old. Lesions on the head and neck were more frequent among children 0\u20135 years, and lesions below the head\/neck were more frequent among 11- to 14-year-old children (<jats:italic>P<\/jats:italic> = 0.004). Using PAHO and WHO criteria, 26% and 53% of children, respectively, were eligible for local treatment. Recommended local treatments for New World CL have potential but limited applicability in children. Individual risk\u2013benefit assessment and effectiveness data in children may increase eligibility.<\/jats:p>","DOI":"10.4269\/ajtmh.12-0784","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T04:23:58Z","timestamp":1372134238000},"page":"359-364","source":"Crossref","is-referenced-by-count":19,"title":["Clinical and Epidemiologic Profile of Cutaneous Leishmaniasis in Colombian Children: Considerations for Local Treatment"],"prefix":"10.4269","volume":"89","author":[{"given":"Victor M.","family":"Blanco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Cossio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier D.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy Gore","family":"Saravia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Am J Trop Med Hyg","first-page":"187","article-title":"Treatment failure in children in a randomized clinical trial with 10 and 20 days of meglumine antimonate for cutaneous leishmaniasis due to Leishmania Viannia species","volume":"64","author":"Palacios","year":"2001"},{"key":"R2","series-title":"J Infect Dis","first-page":"602","article-title":"Pharmacokinetics of antimony in children treated for leishmaniasis with meglumine antimoniate","volume":"195","author":"Cruz","year":"2007"},{"key":"R3","series-title":"J Infect Dis","first-page":"684","article-title":"Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children","volume":"205","author":"Rubiano","year":"2012"},{"key":"R4","series-title":"PLoS Negl Trop Dis","first-page":"e912","article-title":"Miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Brazil: a randomized and controlled trial","volume":"4","author":"Machado","year":"2010"},{"key":"R5","series-title":"Am J Trop Med Hyg","first-page":"255","article-title":"Randomized controlled clinical trial to access efficacy and safety of miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania (Viannia) guyanensis in Manaus, Brazil","volume":"84","author":"Chrusciak-Talhari","year":"2011"},{"key":"R6","series-title":"Trans R Soc Trop Med Hyg","first-page":"141","article-title":"Cutaneous leishmaniasis in western Venezuela caused by infection with Leishmania venezuelensis and L. braziliensis variants","volume":"86","author":"Bonfante-Garrido","year":"1992"},{"key":"R7","series-title":"Pediatr Dermatol","first-page":"455","article-title":"Tegumentary leishmaniasis in chilhood","volume":"13","author":"Bittencourt","year":"1996"},{"year":"1991","series-title":"Information on the Epidemiology and Control of the Leishmaniasis by Country or Territory","author":"Desjeux","key":"R8"},{"key":"R9","series-title":"Am J Trop Med Hyg","first-page":"704","article-title":"Leishmaniasis in Bolivia: comprehensive review and current status","volume":"80","author":"Garc\u00eda","year":"2009"},{"key":"R10","series-title":"Acta Trop","first-page":"155","article-title":"Changing epidemiology of American cutaneous leishmaniasis (ACL) in Brazil: a disease of the urban-rural interface","volume":"90","author":"Oliveira","year":"2004"},{"key":"R11","series-title":"Mem Inst Oswaldo Cruz","first-page":"119","article-title":"Report of an epidemic outbreak of tegumentary leishmaniasis in a coffee-growing area of Colombia","volume":"85","author":"Montoya","year":"1990"},{"key":"R12","series-title":"Wkly Epidemiol Rec","first-page":"365","article-title":"Urbanization: an increasing risk factor for leishmaniasis","volume":"77","author":"World Health Organization","year":"2002"},{"year":"2010","series-title":"Control of the Leishmaniasis: Report of the Meeting of the WHO Expert Committee on the Control of Leishmaniasis. 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