{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:40:03Z","timestamp":1723059603426},"reference-count":13,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,10]]},"abstract":"<jats:p>Previously, we have shown that persons with human immunodeficiency virus 1 (HIV-1) infection and reduced CD4<jats:sup>+<\/jats:sup> T-lymphocyte counts excrete significantly fewer <jats:italic>Schistosoma mansoni<\/jats:italic> eggs than HIV-1\u2013negative persons with similar intensities of schistosome infections. To determine how antiretroviral therapy (ART) might affect egg excretion, we conducted a study of HIV+ adults living in an area highly endemic for <jats:italic>S. mansoni<\/jats:italic> as they began an ART program. Fecal egg excretion and CD4<jats:sup>+<\/jats:sup> T-lymphocyte counts were evaluated at enrollment as well as 2 and 4 weeks after initiation of ART. Fourteen individuals who were Kato\u2013Katz-negative at enrollment subsequently started excreting <jats:italic>S. mansoni<\/jats:italic> eggs accompanied by a significant increase in CD4<jats:sup>+<\/jats:sup> T lymphocytes (<jats:italic>P<\/jats:italic> = 0.004). Study participants who were <jats:italic>S. mansoni<\/jats:italic> egg-positive at enrollment and received both praziquantel and ART also showed significantly increased CD4<jats:sup>+<\/jats:sup> T-lymphocyte counts compared with baseline (<jats:italic>P<\/jats:italic> &lt; 0.0001). Our data support a role for CD4<jats:sup>+<\/jats:sup> T lymphocytes in <jats:italic>S. mansoni<\/jats:italic> egg excretion.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0045","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T04:51:18Z","timestamp":1368507078000},"page":"42-45","source":"Crossref","is-referenced-by-count":7,"title":["Association Between CD4+ T-Lymphocyte Counts and Fecal Excretion of Schistosoma mansoni Eggs in Patients Coinfected with S. mansoni and Human Immunodeficiency Virus Before and After Initiation of Antiretroviral Therapy"],"prefix":"10.4269","volume":"89","author":[{"given":"Erick M. O.","family":"Muok","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elses W.","family":"Simiyu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Ochola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zipporah W.","family":"Ng'ang'a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Evan","family":"Secor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana M. S.","family":"Karanja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline N. 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