{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:55:42Z","timestamp":1789631742928,"version":"build-2803163510"},"reference-count":46,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5,7]]},"abstract":"<jats:p>There is still no well-established consensus about the clinical management of hydatidosis. Currently, surgery continues to be the first therapeutic option, although treatment with anti-parasitic drugs is indicated as an adjuvant to surgery to decrease the number of relapses and hydatid cyst size. When surgery is not possible, medical treatment is indicated. Traditionally, albendazole was used in monotherapy as the standard treatment. However, combined therapy with albendazole plus praziquantel appears to improve anti-parasitic effectiveness. To date, no safety studies focusing on such combined therapy have been published for the treatment of hydatidosis. In this work, we analyze the adverse effects seen in 57 patients diagnosed with hydatidosis who were treated with praziquantel plus albendazole combined therapy between 2006 and 2010.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0059","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T03:17:37Z","timestamp":1394507857000},"page":"819-822","source":"Crossref","is-referenced-by-count":41,"title":["Safety of the Combined Use of Praziquantel and Albendazole in the Treatment of Human Hydatid Disease"],"prefix":"10.4269","volume":"90","author":[{"given":"Luc\u00eda","family":"Alvela-Su\u00e1rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Velasco-Tirado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moncef","family":"Belhassen-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Novo-Veleiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Pardo-Lled\u00edas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Romero-Alegr\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"P\u00e9rez del Villar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Paz","family":"Valverde-Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Cordero-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Emerg Infect Dis","first-page":"296","article-title":"Global socioeconomic impact of cystic echinococcosis","volume":"12","author":"Budke","year":"2006"},{"key":"R2","series-title":"N Engl J Med","first-page":"1018","article-title":"Control of neglected tropical diseases","volume":"357","author":"Hotez","year":"2007"},{"key":"R3","series-title":"Acta Trop","first-page":"191","article-title":"Overview of the epidemiological situation on echinococcosis in the Mediterranean region","volume":"85","author":"Seimenis","year":"2003"},{"key":"R4","series-title":"Acta Trop","first-page":"197","article-title":"Hydatidosis-echinococcosis in Greece","volume":"85","author":"Sotiraki","year":"2003"},{"key":"R5","series-title":"J Helminthol","first-page":"261","article-title":"Distribution of echinococcosis\/hydatidosis in Italy","volume":"61","author":"Lorenzini","year":"1987"},{"key":"R6","series-title":"PLoS Negl Trop Dis","first-page":"e893","article-title":"Cystic echinococcosis in Spain: current situation and relevance for other endemic areas in Europe","volume":"5","author":"Rojo-Vazquez","year":"2011"},{"key":"R7","series-title":"Enferm Infecc Microbiol Clin","first-page":"266","article-title":"Hydatidosis in the province of Salamanca (Spain): should we let down our guard?","volume":"23","author":"Pardo","year":"2005"},{"key":"R8","series-title":"Expert Rev Anti Infect Ther","first-page":"145","article-title":"Benzimidazoles for the treatment of cystic and alveolar echinococcosis: what is the consensus?","volume":"7","author":"Vuitton","year":"2009"},{"key":"R9","series-title":"Bull World Health Organ","first-page":"231","article-title":"Guidelines for treatment of cystic and alveolar echinococcosis in humans. 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