{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:04:54Z","timestamp":1780581894992,"version":"3.54.1"},"reference-count":38,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,10]]},"abstract":"<jats:p>Abu Hamed, Sudan, the northernmost location of onchocerciasis in the world, began community-directed treatment with ivermectin (CDTI) in 1998, with annual treatments enhanced to semiannual in 2007. We assessed the status of the parasite transmission in 2011 entomologically, parasitologically, and serologically. O-150 pool screening showed no parasite DNA in 17,537 black flies collected in 2011 (95% confidence interval upper limit [95% CI UL] = 0.023). Skin microfilariae, nodules, and signs of skin disease were absent in 536 individuals in seven local communities. Similarly, no evidence of <jats:italic>Onchocerca volvulus<\/jats:italic> Ov16 antibodies was found in 6,756 school children \u2264 10 years (95% CI UL = 0.03%). Because this assessment of the focus meets the 2001 World Health Organization (WHO) criteria for interrupted transmission, treatment was halted in 2012, and a post-treatment surveillance period was initiated in anticipation of declaration of disease elimination in this area. We provide the first evidence in East Africa that long-term CDTI alone can interrupt transmission of onchocerciasis.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0112","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T05:08:13Z","timestamp":1369112893000},"page":"51-57","source":"Crossref","is-referenced-by-count":61,"title":["Interruption of Onchocerca volvulus Transmission in the Abu Hamed Focus, Sudan"],"prefix":"10.4269","volume":"89","author":[{"given":"Tarig B.","family":"Higazi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isam M. 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