{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:01:44Z","timestamp":1775476904251,"version":"3.50.1"},"reference-count":8,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,5]]},"abstract":"<jats:p>Although ivermectin treatment can induce serious adverse events (SAEs) in individuals harboring high <jats:italic>Loa loa<\/jats:italic> microfilaremia (mf), not all patients with high mf levels develop such reactions, suggesting that cofactors may be involved. A study was conducted in Cameroon to investigate the possible role of <jats:italic>Plasmodium<\/jats:italic> coinfection at the time of ivermectin treatment in the development of SAEs. Before their first ivermectin treatment, thick smears were obtained from 4,175 individuals to determine the burden of <jats:italic>Plasmodium<\/jats:italic> sp., <jats:italic>L. loa<\/jats:italic>, and <jats:italic>Mansonella perstans<\/jats:italic>. After treatment, 18 (4.3 per 1,000) patients developed a non-neurologic SAE. Logistic regression analysis, adjusting for age, sex, <jats:italic>P. falciparum<\/jats:italic> infection, and <jats:italic>M. perstans<\/jats:italic> infection intensities, confirmed that <jats:italic>L. loa<\/jats:italic> mf was the main risk factor for SAEs. We found no evidence that coinfection with <jats:italic>P. falciparum<\/jats:italic> at the time of ivermectin treatment was associated with the occurrence of <jats:italic>Loa<\/jats:italic>-related SAEs in this population.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0189","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T05:33:27Z","timestamp":1389677607000},"page":"335-338","source":"Crossref","is-referenced-by-count":5,"title":["Absence of an Association Between Plasmodium falciparum Infection and Post-Ivermectin Loa-Related Non-Neurologic Serious Adverse Events"],"prefix":"10.4269","volume":"90","author":[{"given":"Jo\u00ebl","family":"Fokom-Domgue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien D.","family":"Pion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raceline","family":"Gounoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Akame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Nguipdop-Djomo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana A. Y.","family":"Twum-Danso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Thylefors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Boussinesq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Kamgno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"PLoS Negl Trop Dis","first-page":"e1210","article-title":"The geographic distribution of Loa loa in Africa: results of large-scale implementation of the rapid assessment procedure for loiasis (RAPLOA)","volume":"5","author":"Zour\u00e9","year":"2011"},{"issue":"(Suppl 1)","key":"R2","series-title":"Filaria J","first-page":"S4","article-title":"Clinical picture, epidemiology and outcome of Loa-associated serious adverse events related to mass ivermectin treatment of onchocerciasis in Cameroon","volume":"2","author":"Boussinesq","year":"2003"},{"key":"R3","series-title":"Lancet","first-page":"18","article-title":"Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection","volume":"350","author":"Gardon","year":"1997"},{"key":"R4","series-title":"Am J Trop Med Hyg","first-page":"1056","article-title":"Loa loa microfilarial periodicity in ivermectin-treated patients: comparison between those developing and those free of serious adverse events","volume":"81","author":"Kamgno","year":"2009"},{"key":"R5","series-title":"Am J Trop Med Hyg","first-page":"28","article-title":"Analysis of the mdr-1 gene in patients co-infected with Onchocerca volvulus and Loa loa who experienced a post-ivermectin serious adverse event","volume":"83","author":"Bourguinat","year":"2010"},{"key":"R6","series-title":"PLoS One","first-page":"e4317","article-title":"Retinal pathology of pediatric cerebral malaria in Malawi","volume":"4","author":"White","year":"2009"},{"key":"R7","series-title":"Am J Trop Med Hyg","first-page":"546","article-title":"Encephalopathy after ivermectin treatment in a patient infected with Loa loa and Plasmodium spp","volume":"78","author":"Kamgno","year":"2008"},{"issue":"(Suppl 1)","key":"R8","series-title":"Filaria J","first-page":"S3","article-title":"Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases","volume":"2","author":"Twum-Danso","year":"2003"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/90\/2\/article-p335.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/90\/2\/article-p335.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/90\/2\/article-p335.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:33:04Z","timestamp":1723066384000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/90\/2\/article-p335.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,5]]},"references-count":8,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.13-0189","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,5]]}}}