{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:33:18Z","timestamp":1789824798763,"version":"4.0.1"},"reference-count":43,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,4]]},"abstract":"<jats:p>Artesunate (AS) in combination with sulfadoxine\/pyrimethamine (SP) is the first-line therapy for management of uncomplicated <jats:italic>Plasmodium falciparum<\/jats:italic> malaria in Sudan. The objective of this study was to assess the potential impact of SP on the pharmacokinetics of AS and its active metabolite, dihydroartemisinin (DHA), in healthy adults. A single-dose, randomized, open-label, crossover study design with a washout period of three weeks was performed with 16 volunteers. After oral administration of AS alone or in combination with SP, T<jats:sub>max<\/jats:sub> values of AS and DHA were significantly prolonged in the combination group (<jats:italic>P<\/jats:italic> &lt; 0.05). However, there was no significant effect on the other pharmacokinetic parameters (<jats:italic>P<\/jats:italic> &gt; 0.05). The t<jats:sub>1\/2<\/jats:sub> values of AS and DHA were significantly higher in females than in males (<jats:italic>P<\/jats:italic> &lt; 0.05). The present findings suggest that co-administration of SP with AS has no clinically relevant impact on the pharmacokinetics of AS or DHA in healthy persons.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0283","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T03:17:37Z","timestamp":1394507857000},"page":"1087-1093","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacokinetics of Artesunate Alone and in Combination with Sulfadoxine\/Pyrimethamine in Healthy Sudanese Volunteers"],"prefix":"10.4269","volume":"90","author":[{"given":"Kamal M.","family":"Matar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelmoneim I.","family":"Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakina B.","family":"Elamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Guidelines for the Treatment of Malaria, 2011","author":"World Health Organization","year":"2011"},{"key":"R2","series-title":"J Exp Biol","first-page":"35753","article-title":"Review article: antimalarial compound from bench to bedside","volume":"206","author":"Olliaro","year":"2003"},{"issue":"(Suppl)","key":"R3","series-title":"Gezira J Health Sci","first-page":"47","article-title":"Malaria in Sudan: past, present and the future","volume":"1","author":"Malik","year":"2004"},{"key":"R4","series-title":"Saudi Med J","first-page":"147","article-title":"A randomized comparison of sulphadoxinepyrimethamine and combination of sulphadoxine pyrimethamine with chloroquine in the treatment of uncomplicated falciparum malaria in eastern Sudan","volume":"26","author":"Salah","year":"2005"},{"key":"R5","series-title":"Trans R Soc Trop Med Hyg","first-page":"229","article-title":"Chloroquine, sulfadoxine-pyrimethamine and amodiaquine efficacy for the treatment of uncomplicated Plasmodium falciparum malaria in Upper Nile, south Sudan","volume":"97","author":"van den Broek","year":"2003"},{"key":"R6","series-title":"Global Antimalarial Drug Policies database-AFRO: 2006. 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