{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:36:30Z","timestamp":1784590590741,"version":"3.55.0"},"reference-count":46,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,2,5]]},"abstract":"<jats:p>The resistance index (RI), pulsatility index (PI), fetal biometry, fetal heart rate (FHR), placental thickness, and hemoglobin levels were compared in 30 <jats:italic>Plasmodium vivax<\/jats:italic>-infected women between 14 and 20 weeks of pregnancy and a control group. Evaluations were performed at the moment of the malaria diagnosis and 26 weeks of pregnancy. The malaria group had lower levels of hemoglobin and greater placental thickness in both assessments, higher FHR in the first evaluation, and lower values on fetal biometry in the second assessment. There were no differences when comparing RI and PI on umbilical arteries between the two groups. Birth weight and height were lower in newborns in the malaria group than the control group. The results suggest that <jats:italic>P. vivax<\/jats:italic> infections at an earlier gestational age do not affect umbilical arteries blood flow but do affect fetal biometry in the second trimester of pregnancy and at birth.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0285","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T05:33:27Z","timestamp":1389677607000},"page":"371-376","source":"Crossref","is-referenced-by-count":20,"title":["Effects of Vivax Malaria Acquired Before 20 Weeks of Pregnancy on Subsequent Changes in Fetal Growth"],"prefix":"10.4269","volume":"90","author":[{"given":"Amantino C.","family":"Machado Filho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elenice P.","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emely P.","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iracema S.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanoela A. 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Dis","first-page":"638","article-title":"On the cytoadhesion of Plasmodium vivax-infected erythrocytes","volume":"202","author":"Carvalho","year":"2010"},{"key":"R5","series-title":"PLoS One","first-page":"e34509","article-title":"Plasmodium vivax adherence to placental glycosaminoglycans","volume":"7","author":"Chotivanich","year":"2012"},{"key":"R6","series-title":"PLoS Negl Trop Dis","first-page":"e2155","article-title":"Rosetting in Plasmodium vivax: a cytoadhesion phenotype associated with anaemia","volume":"7","author":"Marin-Men\u00e9ndez","year":"2013"},{"key":"R7","series-title":"J Infect Dis","first-page":"1904","article-title":"Placental infection with Plasmodium vivax: a histopathological and molecular study","volume":"206","author":"Mayor","year":"2012"},{"key":"R8","series-title":"Trends Parasitol","first-page":"220","article-title":"The pathophysiology of vivax malaria","volume":"25","author":"Anstey","year":"2009"},{"key":"R9","series-title":"Placenta","first-page":"359","article-title":"The sick placenta-the role of malaria","volume":"25","author":"Brabin","year":"2004"},{"key":"R10","series-title":"Am J Trop Med Hyg","first-page":"79","article-title":"Vivax malaria: neglected and not benign","volume":"77","author":"Price","year":"2007"},{"key":"R11","series-title":"Eur J Obstet Gynecol Reprod Biol","first-page":"136","article-title":"Acute reversible placental dysfunction and abnormal fetal heart rate at delivery","volume":"110","author":"Carles","year":"2003"},{"key":"R12","series-title":"Am J Trop Med Hyg","first-page":"398","article-title":"The effects of Plasmodium falciparum and P. vivax infections on placental histopathology in an area of low malaria transmission","volume":"70","author":"McGready","year":"2004"},{"key":"R13","series-title":"J Ultrasound Med","first-page":"223","article-title":"Fetal cerebral and umbilical artery blood flow changes during pregnancy complicated by malaria","volume":"17","author":"Arbeille","year":"1998"},{"key":"R14","series-title":"Ultrasound Obstet Gynecol","first-page":"165","article-title":"Impaired uteroplacental blood flow in pregnancies complicated by falciparum malaria","volume":"19","author":"Dorman","year":"2002"},{"key":"R15","series-title":"Ultrasound Obstet Gynecol","first-page":"130","article-title":"Fetal biometrics, umbilical and uterine artery Doppler studies among malaria infected and not infected pregnant women","volume":"38","author":"Dent","year":"2011"},{"key":"R16","series-title":"PLoS One","first-page":"e31411","article-title":"Ultrasound evidence of early fetal growth restriction after maternal malaria infection","volume":"7","author":"Rijken","year":"2012"},{"key":"R17","series-title":"Rev Panam Salud Publica","first-page":"203","article-title":"Impact of malaria during pregnancy in the Amazon region","volume":"26","author":"Chagas","year":"2009"},{"key":"R18","series-title":"Mem Inst Oswaldo Cruz","first-page":"19","article-title":"Malaria during pregnancy in a reference centre from the Brazilian Amazon: unexpected increase in the frequency of Plasmodium falciparum infections","volume":"99","author":"Martinez-Espinosa","year":"2004"},{"key":"R19","series-title":"Am J Obstet Gynecol","first-page":"192","article-title":"Pregnancy surveillance with Doppler velocimetry of uterine and umbilical arteries","volume":"160","author":"Schulman","year":"1989"},{"key":"R20","series-title":"Rev Prat","first-page":"4671","article-title":"Indications of Doppler's ultrasonography in the study of peripheral vessels","volume":"25","author":"Pourcelot","year":"1975"},{"key":"R21","series-title":"Proc R Soc Med","first-page":"447","article-title":"Arterial assessment by Doppler-shift ultrasound","volume":"67","author":"Gosling","year":"1974"},{"key":"R22","series-title":"Pediatr Res","first-page":"205","article-title":"Differences in size at birth are determined by differences in growth velocity during early prenatal life","volume":"57","author":"Milani","year":"2005"},{"key":"R23","series-title":"PLoS Negl Trop Dis","first-page":"e2071","article-title":"Placental histopathological changes associated with Plasmodium vivax infection during pregnancy","volume":"7","author":"Souza","year":"2013"},{"key":"R24","series-title":"Malar J","first-page":"319","article-title":"Effect of malaria on placental volume measured using three-dimensional ultrasound: a pilot study","volume":"11","author":"Rijken","year":"2012"},{"key":"R25","series-title":"Lancet","first-page":"546","article-title":"Effects of Plasmodium vivax malaria in pregnancy","volume":"354","author":"Nosten","year":"1999"},{"key":"R26","series-title":"Lancet","first-page":"1747","article-title":"Increased fetoplacental angiogenesis during first trimester in anaemic women","volume":"352","author":"Kadyrov","year":"1998"},{"key":"R27","series-title":"J Gynecol Obstet Biol Reprod (Paris)","first-page":"697","article-title":"Fetal circulation and malaria","volume":"26","author":"Arbeille","year":"1997"},{"key":"R28","series-title":"J Gynecol Obstet Biol Reprod (Paris)","first-page":"798","article-title":"Pregnancy and malaria. Study of 143 cases in French Guyana","volume":"27","author":"Carles","year":"1998"},{"key":"R29","series-title":"Am J Obstet Gynecol","first-page":"1055","article-title":"Effect of placental embolization on the umbilical arterial velocity waveform in fetal sheep","volume":"161","author":"Morrow","year":"1989"},{"key":"R30","series-title":"Ultrasound Med Biol","first-page":"861","article-title":"Assessment of the fetal PO2 changes by cerebral and umbilical Doppler on lamb fetuses during acute hypoxia","volume":"21","author":"Arbeille","year":"1995"},{"key":"R31","series-title":"J Infect Dis","first-page":"561","article-title":"Placental malaria-associated inflammation disturbs the insulin-like growth factor axis of fetal growth regulation","volume":"203","author":"Umbers","year":"2011"},{"key":"R32","series-title":"Mediterr J Hematol Infect Dis","first-page":"e2013010","article-title":"Malaria in pregnancy","volume":"5","author":"Takem","year":"2013"},{"key":"R33","series-title":"Yale J 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Papua","volume":"77","author":"Barcus","year":"2007"},{"key":"R37","series-title":"Am J Med","first-page":"e9","article-title":"Is anemia in Plasmodium vivax malaria more frequent and severe than in Plasmodium falciparum?","volume":"119","author":"Rodriguez-Morales","year":"2006"},{"key":"R38","series-title":"J Vector Borne Dis","first-page":"299","article-title":"Spectrum of vivax malaria in pregnancy and its outcome: a hospital-based study","volume":"46","author":"Nayak","year":"2009"},{"key":"R39","series-title":"BJOG","first-page":"1189","article-title":"Malaria in pregnancy","volume":"112","author":"Whitty","year":"2005"},{"key":"R40","series-title":"Emerg Infect Dis","first-page":"132","article-title":"Plasmodium vivax malaria","volume":"11","author":"Kochar","year":"2005"},{"key":"R41","series-title":"Trans R Soc Trop Med Hyg","first-page":"416","article-title":"The effect of timing and frequency of Plasmodium falciparum infection during pregnancy on the risk of low birth weight 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