{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T08:12:14Z","timestamp":1746605534659},"reference-count":52,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,8]]},"abstract":"<jats:p>We conducted a longitudinal analysis of 117 lymphedema patients in a filariasis-endemic area of Haiti during 1995\u20132008. No difference in lymphedema progression between those who received or did not receive mass drug administration (MDA) was found on measures of foot (<jats:italic>P<\/jats:italic> = 0.24), ankle (<jats:italic>P<\/jats:italic> = 0.87), or leg (<jats:italic>P<\/jats:italic> = 0.46) circumference; leg volume displacement (<jats:italic>P<\/jats:italic> = 0.09), lymphedema stage (<jats:italic>P<\/jats:italic> = 0.93), or frequency of adenolymphangitis (ADL) episodes (<jats:italic>P<\/jats:italic> = 0.57). Rates of ADL per year were greater after initiation of MDA among both groups (<jats:italic>P<\/jats:italic> &lt; 0.01). Nevertheless, patients who received MDA reported improvement in four areas of lymphedema-related quality of life (<jats:italic>P<\/jats:italic> \u2264 0.01). Decreases in foot and ankle circumference and ADL episodes were observed during the 1995-1998 lymphedema management study (<jats:italic>P<\/jats:italic> \u2264 0.01). This study represents the first longitudinal, quantitative, leg-specific analysis examining the clinical effect of diethylcarbamazine on lymphedema progression and ADL episodes.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0317","type":"journal-article","created":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T04:28:19Z","timestamp":1384230499000},"page":"80-88","source":"Crossref","is-referenced-by-count":5,"title":["A Longitudinal Analysis of the Effect of Mass Drug Administration on Acute Inflammatory Episodes and Disease Progression in Lymphedema Patients in L\u00e9ogane, Haiti"],"prefix":"10.4269","volume":"90","author":[{"given":"Brittany A.","family":"Eddy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna J.","family":"Blackstock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John 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