{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:21:16Z","timestamp":1780104076291,"version":"3.54.0"},"reference-count":24,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,6]]},"abstract":"<jats:p>Calcified <jats:italic>Taenia solium<\/jats:italic> granulomas are the focus of repeated episodes of perilesional edema and seizures in 50% of persons with calcifications, history of seizures, and a positive serology for cysticercosis. The pathophysiology is unclear but recent studies suggest the edema is caused by inflammation. We report two new cases and four other published cases where cessation of corticosteroids appeared to result in recurrence or new appearance of perilesional edema around calcifications. This suggests that perilesional edema is an immune-mediated phenomenon.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0350","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T02:10:21Z","timestamp":1378260621000},"page":"919-923","source":"Crossref","is-referenced-by-count":31,"title":["Corticosteroid Withdrawal Precipitates Perilesional Edema around Calcified Taenia solium Cysts"],"prefix":"10.4269","volume":"89","author":[{"given":"Rojelio","family":"Mejia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore E.","family":"Nash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"PLoS Negl Trop Dis","first-page":"e870","article-title":"A systematic review of the frequency of neurocyticercosis with a focus on people with epilepsy","volume":"4","author":"Ndimubanzi","year":"2010"},{"key":"R2","series-title":"Nat Rev Nephrol","first-page":"584","article-title":"Diagnosis and treatment of neurocysticercosis","volume":"7","author":"Nash","year":"2011"},{"key":"R3","series-title":"Lancet Neurol","first-page":"1099","article-title":"Perilesional brain oedema and seizure activity in patients with calcified neurocysticercosis: a prospective cohort and nested case-control study","volume":"7","author":"Nash","year":"2008"},{"key":"R4","series-title":"Neurology","first-page":"1934","article-title":"Calcific neurocysticercosis and epileptogenesis","volume":"62","author":"Nash","year":"2004"},{"key":"R5","series-title":"Clin Infect Dis","first-page":"1649","article-title":"Calcified cysticerci provoke perilesional edema and seizures","volume":"33","author":"Nash","year":"2001"},{"key":"R6","series-title":"Neurology","first-page":"618","article-title":"Understanding epileptogenesis in calcified neurocysticercosis with perfusion MRI","volume":"78","author":"Gupta","year":"2012"},{"key":"R7","series-title":"AJNR Am J Neuroradiol","first-page":"79","article-title":"Persistent MR contrast enhancement of calcified neurocysticercosis lesions","volume":"19","author":"Sheth","year":"1998"},{"key":"R8","series-title":"Clin Infect Dis","first-page":"101","article-title":"Neurocysticercosis: a major cause of neurological disease worldwide","volume":"24","author":"White","year":"1997"},{"key":"R9","series-title":"Neurology","first-page":"1706","article-title":"Prognostic factors for seizure recurrence after withdrawal of antiepileptic drugs in patients with neurocysticercosis","volume":"44","author":"Del Brutto","year":"1994"},{"key":"R10","series-title":"Pathogens and Global Health","first-page":"275","article-title":"Edema surrounding calcified intracranial cysticerci: clinical manifestations, natural history, and treatment","volume":"106","author":"Nash","year":"2012"},{"key":"R11","series-title":"Am J Trop Med Hyg","first-page":"460","article-title":"Short report: a calcified Taenia solium granuloma associated with recurrent perilesional edema causing refractory seizures: histopathological features","volume":"85","author":"Ooi","year":"2011"},{"key":"R12","series-title":"Am J Trop Med Hyg","first-page":"664","article-title":"Reactivation of neurocysticercosis: case report","volume":"60","author":"Sheth","year":"1999"},{"key":"R13","series-title":"Pediatr Infect Dis J","first-page":"581","article-title":"Clinical implications of calcified lesions of neurocysticercosis","volume":"19","author":"Park","year":"2000"},{"key":"R14","series-title":"Clin Infect Dis","first-page":"549","article-title":"Methotrexate as a corticosteroid-sparing agent in complicated neurocysticercosis","volume":"44","author":"Mitre","year":"2007"},{"key":"R15","series-title":"AJNR Am J Neuroradiol","first-page":"653","article-title":"Calcified neurocysticercosis lesions trigger symptomatic inflammation during antiparasitic therapy","volume":"27","author":"Poeschl","year":"2006"},{"key":"R16","series-title":"Cysticercosis of the Central Nervous System","first-page":"27","article-title":"Pathology of the nervous system","author":"Escobar","year":"1983"},{"key":"R17","series-title":"Taenia solium Cysticercosis: From Basics to Clinical Science","first-page":"289","article-title":"The pathology of neurocysticercosis","author":"Escobar","year":"2002"},{"key":"R18","series-title":"PLoS ONE","first-page":"e74052","article-title":"PET reveals inflammation around calcified Taenia solium granulomas with perilesional edema","volume":"8","author":"Masahiro","year":"2013"},{"key":"R19","series-title":"Seizure","first-page":"104","article-title":"Frequency and patterns of MRI abnormalities due to status epilepticus","volume":"18","author":"Milligan","year":"2009"},{"key":"R20","series-title":"Epilepsy Res","first-page":"129","article-title":"Reversible periictal MRI abnormalities: clinical correlates and long-term outcome in 12 patients","volume":"73","author":"Raghavendra","year":"2007"},{"issue":"(Suppl 4)","key":"R21","series-title":"Epilepsia","first-page":"72","article-title":"Status epilepticus and periictal imaging","volume":"45","author":"Cole","year":"2004"},{"key":"R22","series-title":"Handbuch der Neurologie","first-page":"642","article-title":"Die tierischen Parasiten des Zentralnervensystems","author":"Henneberg","year":"1912"},{"key":"R23","series-title":"Pathology of Protozoal and Helminthic Diseases","first-page":"592","article-title":"Cysticercosis","author":"Marquez-Monter","year":"1971"},{"key":"R24","series-title":"Neurology","first-page":"777","article-title":"Edema associated with calcified lesions in neurocysticercosis","volume":"53","author":"Nash","year":"1999"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/89\/5\/article-p919.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/89\/5\/article-p919.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/89\/5\/article-p919.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:17:18Z","timestamp":1723054638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/89\/5\/article-p919.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,6]]},"references-count":24,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.13-0350","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,6]]}}}