{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:47:18Z","timestamp":1777045638791,"version":"3.51.4"},"reference-count":39,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,4]]},"abstract":"<jats:p>Therapy for mansonelliasis is challenging because there is no standard drug recommended for its treatment. This non-randomized study was conducted to evaluate the effectiveness of a single dose of 0.15 mg\/kg of ivermectin to reduce <jats:italic>Mansonella ozzardi<\/jats:italic> microfilaraemia in infected persons. A total of 74 patients were studied within the municipality of L\u00e1brea, which is located in Amazonas State, Brazil. The patients were treated with ivermectin after detection of the parasite by blood examination. Significant microfilaraemia reduction was observed and its residual effect was maintained for at least 12 months. There was no significant change in the laboratory blood count, hepatic metabolites, and nitrogen-bounding compound excreta dosage values that could compromise the use of this drug, demonstrating that ivermectin has a low toxicity level.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0410","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T06:06:30Z","timestamp":1396937190000},"page":"1170-1175","source":"Crossref","is-referenced-by-count":21,"title":["Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon"],"prefix":"10.4269","volume":"90","author":[{"given":"Sergio de Almeida","family":"Basano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto","family":"Fontes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jansen Fernandes","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Souza de Almeida Aranha","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana Jana\u00edna Souza","family":"Vera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Paulo Parente","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maira Santiago Pires","family":"Parente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo de Godoi Mattos","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro di T\u00e1rique Barreto","family":"Crispim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds Marcelo Aranha","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Doen\u00e7as Infecciosas e Parasit\u00e1rias, Enfoque Amaz\u00f4nico","first-page":"733","article-title":"Mansonelose","author":"Tavares","year":"1997"},{"key":"R2","series-title":"J Bras Med","first-page":"885","article-title":"Sobre a transmiss\u00e3o da Mansonella ozzardi","volume":"1","author":"Cerqueira","year":"1959"},{"key":"R3","series-title":"Mem Inst Oswaldo Cruz","first-page":"451","article-title":"Simuliid blackflies (Diptera: Simuliidae) and Ceratopogonide midges (Diptera: Ceratopogonidae) as vectors of Mansonella ozzardi (Nematoda: Onchocercidae) in northern Argentina","volume":"96","author":"Shelley","year":"2001"},{"key":"R4","series-title":"Rev Serv Esp Saude Publ","first-page":"849","article-title":"Sobre a incid\u00eancia de fil\u00e1rias humanas em Manaus, estado do Amazonas","volume":"2","author":"Deane","year":"1949"},{"key":"R5","series-title":"Rev Bras Malariol Doencas Trop","first-page":"437","article-title":"Filarioses humanas nas sedes municipais do Estado do Amazonas e territ\u00f3rios do Acre, Guapor\u00e9 Rio Branco","volume":"8","author":"Lacerda","year":"1956"},{"key":"R6","series-title":"Hospital","first-page":"869","article-title":"Estudo sobre a varia\u00e7\u00e3o nictemeral da microfilaremia de Mansonella ozzardi","volume":"56","author":"Moraes","year":"1959"},{"key":"R7","series-title":"Trans R Soc Trop Med Hyg","first-page":"16","article-title":"Mansonella ozzardi microfilariae in skin snips","volume":"70","author":"Moraes","year":"1976"},{"key":"R8","series-title":"Estudo da Infec\u00e7\u00e3o por Mansonella ozzardi","author":"Tavares","year":"1981"},{"key":"R9","series-title":"Cad Saude Publica","first-page":"1421","article-title":"Ocorr\u00eancia da Mansonella ozzardi (Nematoda, Onchocercidae) em comunidades ribeirinhas do rio Purus, Munic\u00edpio de Boca do Acre, Amazonas, Brasil","volume":"25","author":"Medeiros","year":"2008"},{"key":"R10","series-title":"Mem Inst Oswaldo Cruz","first-page":"74","article-title":"Mansonella ozzardi in Brazil: prevalence of infection in riverine communities in the Purus region, in the state of Amazonas","volume":"104","author":"Medeiros","year":"2009"},{"key":"R11","series-title":"Rev Soc Bras Med Trop","first-page":"186","article-title":"Prevalence of Mansonella ozzardi among riverine communities in the Labrea municipality, State of Amazonas, Brazil","volume":"44","author":"Medeiros","year":"2011"},{"key":"R12","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"281","article-title":"Estudo da patogenicidade da Mansonella ozzardi e da sintomatologia da mansonelose","volume":"2","author":"Batista","year":"1960"},{"key":"R13","series-title":"Hospital","first-page":"301","article-title":"Filarioses humanas na cidade de Manaus","volume":"56","author":"Oliveira","year":"1961"},{"key":"R14","series-title":"Arq Bras Oftalmol","first-page":"674","article-title":"Achados oculares entre habitantes do munic\u00edpio de Pauini e poss\u00edvel associa\u00e7\u00e3o entre les\u00f5es corneanas e mansonelose na Amaz\u00f4nia","volume":"61","author":"Branco","year":"1998"},{"key":"R15","series-title":"Cornea","first-page":"817","article-title":"First report of presumed parasititic keratitis in indians from the Brazilian Amazon","volume":"19","author":"Garrido","year":"2001"},{"key":"R16","series-title":"BMJ Open","first-page":"1","article-title":"Mansonella ozzardi corneal lesions in the Amazon: a cross-sectional study","volume":"27","author":"Vianna","year":"2012"},{"key":"R17","series-title":"Am J Trop Med Hyg","first-page":"830","article-title":"Mansonella ozzardi infection in Bolivia: prevalence and clinical associations in the Chaco region","volume":"61","author":"Bartoloni","year":"1999"},{"key":"R18","series-title":"West Indian Med J","first-page":"231","article-title":"Ivermectin treatment of mansonellosis in Trinidad","volume":"48","author":"Gonzalez","year":"1999"},{"key":"R19","series-title":"J Infect Dis","first-page":"662","article-title":"Ivermectin in the successful treatment of a patient with Mansonella ozzardi infection","volume":"156","author":"Nutman","year":"1987"},{"key":"R20","series-title":"PLoS Negl Trop Dis","first-page":"e1254","article-title":"Randomized clinical trial on ivermectin versus thiabendazole for the treatment of strongyloidiasis","volume":"5","author":"Bisoffi","year":"2011"},{"key":"R21","series-title":"Int J Antimicrob Agents","first-page":"46","article-title":"Efficacy and safety of a single-dose veterinary preparation of ivermectin versus 7-day high-dose albendazole for chronic strongyloidiasis","volume":"31","author":"Suputtamongkol","year":"2008"},{"key":"R22","series-title":"Acta Trop","first-page":"190","article-title":"A randomized, double-blind, multicenter clinical trial on the efficacy of ivermectin against intestinal nematode infections in China","volume":"106","author":"Wen","year":"2008"},{"key":"R23","series-title":"Am J Trop Med Hyg","first-page":"304","article-title":"Ivermectin for human strongyloidiasis and other intestinal helminths","volume":"40","author":"Naquira","year":"1989"},{"key":"R24","series-title":"Rev Soc Bras Med Trop","first-page":"69","article-title":"Preval\u00eancia de parasitoses intestinais na cidade de Eirunep\u00e9, Amazonas","volume":"38","author":"Ara\u00fajo","year":"2005"},{"key":"R25","series-title":"Bol Soc Venez Microbiol","first-page":"131","article-title":"Estudio del efecto de ivermectina en helmintos intestinales en comunidades yanomamis del Alto Orinoco Estado Amazonas Venezuela","volume":"20","author":"G\u00f3mez","year":"2000"},{"key":"R26","series-title":"Popula\u00e7\u00f5es e Domic\u00edlios \u2013 Brasil, Censo 2007","author":"Instituto Brasileiro de Geografia e Estat\u00edstica \u2013 IBGE","year":"2010"},{"key":"R27","series-title":"Health Technol Assess","first-page":"1","article-title":"Evaluating non-randomised intervention studies","volume":"7","author":"Deeks","year":"2003"},{"key":"R28","series-title":"J Parasitol","first-page":"623","article-title":"A simplified membrane filtration technique for the diagnosis of microfilaraemia","volume":"56","author":"Chularerk","year":"1970"},{"key":"R29","series-title":"J Antimicrob Chemother","first-page":"195","article-title":"Ivermectin in human medicine","volume":"34","author":"Ottesen","year":"1994"},{"key":"R30","series-title":"Rev Soc Bras Med Trop","first-page":"380","article-title":"Improvement of a PCR test to diagnose infection by Mansonella ozzardi","volume":"44","author":"Vera","year":"2011"},{"key":"R31","series-title":"Lancet","first-page":"171","article-title":"Efficacy and tolerance of ivermectin in human onchocerciasis","volume":"2","author":"Aziz","year":"1982"},{"key":"R32","series-title":"Am J Trop Med Hyg","first-page":"816","article-title":"Detection of the filarial parasite Mansonella streptocerca in skin biopsies by a nested polymerase chain reaction-based assay","volume":"58","author":"Fischer","year":"1998"},{"key":"R33","series-title":"J Infect Dis","first-page":"1403","article-title":"Long term suppression of Mansonella streptocerca microfilariae after treatment with ivermectin","volume":"180","author":"Fischer","year":"1999"},{"key":"R34","series-title":"Ann Trop Med Parasitol","first-page":"827","article-title":"Impact of long-term ivermectin (Mectizan) on Wuchereria bancrofti and Mansonella perstans infections in Burkina Faso: strategic and policy implications","volume":"97","author":"Kyelem","year":"2003"},{"key":"R35","series-title":"Trop Med Int Health","first-page":"1002","article-title":"Impact of long-term (14 years) bi-annual ivermectin on Wuchereria bancrofti microfilaraemia","volume":"10","author":"Kyelem","year":"2005"},{"key":"R36","series-title":"Trop Med Int Health","first-page":"1082","article-title":"Reduction in the prevalence and intensity of infection in Onchorcerca volvulus microfilariae according to ethnicity and community after 8 years of ivermectin treatment on the island of Bioko, Equatorial Guinea","volume":"11","author":"Mas","year":"2006"},{"key":"R37","series-title":"AAPS J","first-page":"42","article-title":"The pharmacokinets and interactions of ivermectin in humans \u2013 A mini-review","volume":"10","author":"Canga","year":"2008"},{"key":"R38","series-title":"Rev Arg Microb","first-page":"48","article-title":"Invermectin-related adverse clinical events in patients treated for Mansonella ozzardi infections","volume":"43","author":"Krolewiecki","year":"2011"},{"key":"R39","series-title":"PLoS Negl Trop Dis","first-page":"e1549","article-title":"A research agenda for helminth diseases of humans: intervention for control and elimination","volume":"6","author":"Prichard","year":"2012"}],"container-title":["The American Society of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/90\/6\/article-p1170.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/90\/6\/article-p1170.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/90\/6\/article-p1170.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:23:43Z","timestamp":1723065823000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/90\/6\/article-p1170.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,4]]},"references-count":39,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.13-0410","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,4]]}}}