{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:24:15Z","timestamp":1783574655067,"version":"3.55.0"},"reference-count":16,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:p>The <jats:italic>Yersinia pestis<\/jats:italic> chromosome contains a large variety and number of insert sequences that have resulted in frequent chromosome rearrangement events. To identify the chromosomal rearrangement features of <jats:italic>Y. pestis<\/jats:italic> strains from five typical plague foci in China and study spontaneous DNA rearrangements potentially stabilized in certain lineages of <jats:italic>Y. pestis<\/jats:italic> genomes, we examined the linking mode of locally collinear blocks (LCBs) in 30 <jats:italic>Y. pestis<\/jats:italic> strains by a polymerase chain reaction-based method. Our results suggest most strains have relatively stable chromosomal arrangement patterns, and these rearrangement characteristics also have a very close relationship with the geographical origin. In addition, some LCB linking modes are only present in specific strains. We conclude <jats:italic>Y. pestis<\/jats:italic> chromosome rearrangement patterns may reflect the genetic features of specific geographical areas and can be applied to distinguish <jats:italic>Y. pestis<\/jats:italic> isolates; furthermore, most of the rearrangement events are stable in certain lineages of <jats:italic>Y. pestis<\/jats:italic> genomes.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0491","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T04:02:08Z","timestamp":1407816128000},"page":"722-728","source":"Crossref","is-referenced-by-count":6,"title":["Chromosomal Rearrangement Features of Yersinia pestis Strains from Natural Plague Foci in China"],"prefix":"10.4269","volume":"91","author":[{"given":"Ying","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhikai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongzheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianxu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Hai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"R1","series-title":"Clin 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