{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:40:06Z","timestamp":1723066806714},"reference-count":47,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5,7]]},"abstract":"<jats:p>To determine the association between a range of inherited blood disorders and indicators of poor nutrition, we analyzed data from a population-based, cross-sectional survey of 882 children 6\u201335 months of age in western Kenya. Of children with valid measurements, 71.7% were anemic (hemoglobin &lt; 11 g\/dL), 19.1% had ferritin levels &lt; 12 \u03bcg\/L, and 30.9% had retinol binding protein (RBP) levels &lt; 0.7 \u03bcmol\/L. Unadjusted analyses showed that compared with normal children, homozygous \u03b1<jats:sup>+<\/jats:sup>-thalassemia individuals had a higher prevalence of anemia (82.3% versus 66.8%, <jats:italic>P<\/jats:italic> = 0.001), but a lower prevalence of low RBP (20.5% versus 31.4%, <jats:italic>P<\/jats:italic> = 0.024). In multivariable analysis, homozygous \u03b1<jats:sup>+<\/jats:sup>-thalassemia remained associated with anemia (adjusted odds ratio [aOR] = 1.8, <jats:italic>P<\/jats:italic> = 0.004) but not with low RBP (aOR = 0.6, <jats:italic>P<\/jats:italic> = 0.065). Among young Kenyan children, \u03b1<jats:sup>+<\/jats:sup>-thalassemia is associated with anemia, whereas G6PD deficiency, haptoglobin 2-2, and HbS are not; none of these blood disorders are associated with iron deficiency, vitamin A deficiency, or poor growth.<\/jats:p>","DOI":"10.4269\/ajtmh.13-0496","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T06:17:58Z","timestamp":1395123478000},"page":"955-962","source":"Crossref","is-referenced-by-count":8,"title":["Nutritional Status of Young Children with Inherited Blood Disorders in Western Kenya"],"prefix":"10.4269","volume":"90","author":[{"given":"Becky L.","family":"Tsang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin M.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laird J.","family":"Ruth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas N.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parminder S.","family":"Suchdev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"R1","series-title":"PLoS Med","first-page":"e158","article-title":"The effect of alpha+-thalassemia on the incidence of malaria and other diseases in children living on the coast of Kenya","volume":"3","author":"Wambua","year":"2006"},{"key":"R2","series-title":"BMJ","first-page":"294","article-title":"The variability of sickle-cell rates in the tribes of Kenya and the southern Sudan","volume":"1","author":"Foy","year":"1954"},{"key":"R3","series-title":"Nat Genet","first-page":"1253","article-title":"Negative epistasis between the malaria-protective effects of 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